Mathematical models are proposed to explain the unique subconductance level states in heteromeric Kir4.1/Kir5.1 channels from Xenopustropicalis. The subconductant level states have been confirmed relating to their structure. The modelling results support the co-operatively moving of subunits for the opening of the channel to produce subcontactant level states. It would help to understand the ge...

Discovery, characterization, and structure–activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1 by Raphemot, R., Lonergan, D. F., Nguyen, T. T., Utley, T., Lewis, L. M., Kadakia, R., Weaver, C. D., Gogliotti, R., Hopkins, C., Lindsley, C. W., and Denton, J. S. (2011). Front. Pharmacol. 2:75. doi: 10.3389/ fphar.2011.0...

Bone marrow mesenchymal stem cells (MSCs) are used as a cell source for cardiomyoplasty; however, the cellular electrophysiological properties are not fully understood. The present study was to investigate the functional ionic channels in undifferentiated mouse bone marrow MSCs using whole cell patch-voltage clamp technique, RT-PCR, and Western immunoblotting analysis. We found that three types...

Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels. These channels share all the key structural...