To improve efficiency of isolation of tubercle bacilli from clinical specimens, the following recommendations are presented. (i) Employ multiple specimens consisting of a combination of morning sputums for the early detection of positives, along with 24-hr sputum pools for the greatest total yield of positives. (ii) When timing is rigorously controlled, Zephiran-trisodium phosphate and sodium h...

The human brain is a complex network of anatomically segregated regions interconnected by white matter pathways, known as the human connectome. Diffusion tensor imaging can be used to reconstruct this structural brain network in vivo and noninvasively. However, due to a wide variety of influences, both false positive and false negative connections may occur. By choosing a 'group threshold', bra...

Low-Complexity Regions (LCRs) of biological sequences are the main source of false positives in similarity searches for biological sequence databases. We consider the problem of finding similar sequences when the locations of the LCRs are not known precisely. We develop a formulation to measure the quality of each letter in a sequence. The quality value of a letter is the probability for that l...

Tubulin-dependent GTP hydrolysis was evaluated for its potential as a relatively simple screening assay for new antimitotic drugs. Carbamates of aromatic amines were chosen as the test system because of the relatively diverse structures of compounds in this class already known to have antimitotic properties and because of the large number of such compounds in the NSC collection of the National ...

An incredible amount of data is generated in the course of a functional neuroimaging experiment. The quantity of data gives us improved temporal and spatial resolution with which to evaluate our results. It also creates a staggering multiple testing problem. A number of methods have been created that address the multiple testing problem in neuroimaging in a principled fashion. These methods pla...

Abstract: In research on eye movements in reading, it is common to analyze a number of canonical dependent measures in order to study how the effects of a manipulation unfold over time. Although this gives rise to the well-known multiple comparisons problem, i.e. an inflated probability that the null hypothesis is incorrectly rejected (Type I error), it is accepted standard practice not to appl...