We present a unified rotation curve of the Galaxy re-constructed from the existing data by re-calculating the distances and velocities for a set of galactic constants R0 =8 kpc and V0 =200 km s . We decompose it into a bulge with de Vaucouleurs-law profile of half-mass scale radius 0.5 kpc and mass 1.8×10M⊙, an exponential disk of scale radius 3.5 kpc of 6.5× 10M⊙, and an isothermal dark halo o...

This descriptive study was accomplished on 83 K. pneumoniae strains isolated from two hospitals in Tehran, Iran. Antibiotic susceptibility tests were performed by disc diffusion and broth microdilution methods. ESBLs, MBL, Amp-C, and KPC producing strains were detected by phenotypic confirmatory test, combination disk diffusion test (CDDT), Amp-C detection kit, and modified Hodge test, respecti...

Background Resistance of Klebsiella pneumoniae to carbapenems is mainly associated with acquired carbapenem-hydrolyzing b-lactamases [1]. These b-lactamases can be metallo b-lactamases (IMP, VIM), expanded-spectrum oxacillinases (OXA-48), or Ambler class A enzymes (NMCA, IMI, SME, GES, and KPC) [1,2]. The most common class A carbapenemases in K. pneumoniae are the K. pneumoniae carbapenemases (...

In recent years, there have been increasing reports of KPC-producing Klebsiella pneumoniae in Korea. The modified Hodge test can be used as a phenotypic screening test for class A carbapenamase (CAC)-producing clinical isolates; however, it does not distinguish between carbapenemase types. The confirmation of type of CAC is important to ensure optimal therapy and to prevent transmission. This s...

The multidrug-resistant rate of Klebsiella pneumoniae has risen rapidly worldwide. To better understand the multidrug resistance situation and molecular characterization of Klebsiella pneumoniae, a total of 153 Klebsiella pneumoniae isolates were collected, and drug susceptibility test was performed to detect its susceptibility patterns to 13 kinds of antibiotics. Phenotypic tests for carbapene...

Carbapenemase-producing Klebsiella pneumoniae (KPC) has emerged and spread throughout the world. A retrospective analysis was performed on carbapenem-resistant K. pneumoniae isolated at our teaching hospital during the period 2009-2010, when the initial outbreak occurred. To determine the mechanism(s) that underlies the increased infectivity exhibited by KPC, Multilocus Sequence Typing (MLST) w...

We present an analysis of a 40 ksec Chandra observation of the galaxy group AWM 5. It has a small (∼ 8 kpc) dense cool core with a temperature of ∼ 1.2 keV and the temperature profile decreases at larger radii, from ∼ 3.5 keV just outside the core to ∼ 2 keV at ∼ 300 kpc from the center. The abundance distribution shows a “hole” in the central ∼ 10 kpc, where the temperature declines sharply. A...

Class A carbapenemases are a major threat to the potency of carbapenem antibiotics. A widespread carbapenemase, KPC-2, is not easily inhibited by β-lactamase inhibitors (i.e., clavulanic acid, sulbactam, and tazobactam). To explore different mechanisms of inhibition of KPC-2, we determined the crystal structures of KPC-2 with two β-lactamase inhibitors that follow different inactivation pathway...

The emergence of Klebsiella pneumoniae producing carbapenemase (KPC) has now become a global concern. As a part of a nationwide multicentre surveillance study in Cuba, three K. pneumoniae clinical isolates resistant to carbapenems were detected for a 1-month period (September to October 2011). PCR and sequence analysis revealed that the three strains harboured bla KPC-2. They showed resistance ...

BACKGROUND KPC-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with high mortality; however, their virulence determinants are not well defined. METHODS We investigated the virulence and plasmid transferability among KPC-containing K. pneumoniae isolates. RESULTS KPC-2 and -3 were successfully conjugated and retained by a virulent K2 K. pneumoniae recipi...