نتایج جستجو برای: kruppel
تعداد نتایج: 729 فیلتر نتایج به سال:
There are three different marginal zone lymphomas (MZLs): the extranodal MZL of mucosa-associated lymphoid tissue (MALT) type (MALT lymphoma), the splenic MZL, and the nodal MZL. The three MZLs share common lesions and deregulated pathways but also present specific alterations that can be used for their differential diagnosis. Although trisomies of chromosomes 3 and 18, deletions at 6q23, dereg...
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor of Plk4, a polo-like kinase whose overexpression induces centrosome overduplication. T...
Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zincfinger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF2/2 fetal liver progenitor cells that harbor a single copy of the entire human b-globin locus and then reintroduced EKLF as a tamoxifen-inducible, EKLF–mutant estrogen receptor (EKLF-ERTM) fusion protein....
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