Background: Ethyl carbamate (EC), a byproduct that naturally forms in fermented foods, can cause tumors and cell death is classified as probable human carcinogen (Group 2A). EC formed through the alcoholysis reaction between ethanol carbamyl compounds. The major precursors dominantly emerging stages of differ with disparate food types, including soy sauce. This work aimed to clarify formation i...

Omental adipose stromal cells (O-ASC) are a multipotent population of mesenchymal stem cells contained in the omentum tissue that promote endometrial and ovarian tumor proliferation, migration, and drug resistance. The mechanistic underpinnings of O-ASCs' role in tumor progression and growth are unclear. Here, we propose a novel nitric oxide (NO)-mediated metabolic coupling between O-ASCs and g...

Experiments were designed to examine whether or not insulin-like growth factor I (IGF-I), which is produced by vascular cells in response to injury, affects the production of nitric oxide evoked by the inducible nitric oxide synthase in cultures of smooth muscle cells from the rat aorta. Nitric oxide production was assessed indirectly by the measurement of nitrite accumulation and nitric oxide ...

Maternal malnutrition can elicit gene expression leading to fetal programming. L-citrulline (CIT) can be converted to L-arginine to generate nitric oxide (NO). We examined whether maternal CIT supplementation can prevent N(G)-nitro-L-arginine-methyl ester (L-NAME, NO synthase inhibitor)-induced programmed hypertension and examined their effects on the renal transcriptome in male offspring using...

Single crystals of pure and Li doped L-citrulline oxalate (LCO) crystals are grown successfully by slow evaporation technique. The effect of lithium doping on crystal properties has been studied. The samples are characterized by X-ray powder diffraction, TGA, FTIR, Raman and UV-Vis spectroscopic techniques. The presence of lithium in Li doped LCO crystals is estimated using AES. The thermal sta...

CC was shown to be necessary for the reaction with a partially purified system (l), confirming previous data obtained with cruder preparations (2, 3).’ However, the mechanism of this reaction was not clear, since CG did not disappear during the biosynthesis of citrulline (1). Some insight into the mechanism of the reaction was obtained from kinetic data (l), indicating an “activation” of CG in ...

The endogenous synthesis of arginine, a semiessential amino acid, relies on the production of citrulline by the gut and its conversion into arginine by the kidney in what has been called the "intestinal-renal axis" for arginine synthesis. Although the kidney is the main site for citrulline disposal, it only accounts for ~60-70% of the citrulline produced. Because the only known fate for citrull...