Abstract Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge gap large effective mode volume with experimental quality factor. Relying on transduction mechanism reactive sensing principle, herein, we first numerically study potential subwavelength confin...

Correlating in-brain pH fluctuations with the pathophysiology has been impeded by lack of in vivo techniques to precisely determine local changes. Here, we developed an all-in-one probe for spatially-resolved and label-free sensing vivo, based on a field-effect sensor, i.e., light-addressable potentiometric sensor (LAPS), coupled flexible multimodal fiber. A readout photocurrent from LAPS, elic...