Muscle contraction may increase the rate of glycogen degradation to several hundred times that present at rest (1, 2). The increase in the rate of conversion of glycogen to lactate in isolated frog sartorius performing single twitches requires changes in the activity of at least two enzymes, glycogen phosphorylase and phosphofructokinase (2). The activation of phosphorylase and control of rapid...

The rate of glycolysis in skeletal muscle can apparently be regulated at several discrete metabolic steps. It has been established that epinephrine affects glycolysis by increasing the activity of the phosphorylase reaction (1, 2). The early observation (3) that treatment of isolated frog skeletal muscles with epinephrine under anaerobic conditions causes a large increase in the hexose monophos...

OBJECTIVES Effective assessment of tissue perfusion is highly important during Coronary Artery Bypass Graft (CABG). Mixed venous O2 saturation (Svo2) is one of the best and routinely used markers of tissue perfusion. However, this method is costly and leads to considerable complications. Thus, the present study aimed to determine whether the Svo2 can be substituted with central venous saturatio...

Wittenberger, Charles L. (National Institute of Dental Research, U.S. Public Health Service, Bethesda, Md.), and Ann S. Haaf. Lactate-degrading system in Butyribacterium rettgeri subject to glucose repression. J. Bacteriol. 88:896-903. 1964.-The ability of Butyribacterium rettgeri to utilize lactate as the main energy source for growth requires the formation of a lactate-degrading system. The p...

McArdle (1951) described the case of a man who from early childhood was unable to maintain exercise, because muscle pain and stiffness developed during it. He found that blood concentrations of lactate and pyruvate did not increase in the usual way after exercise in this patient and therefore deduced that there was a defective breakdown of muscle glycogen. Other patients with similar symptoms a...

Abstract Funding Acknowledgements Type of funding sources: None. Background Mortality from cardiogenic shock (CS) shows great disparities (1). This evidence reflects variations in access to care and medical practice, related the lack clear guidelines for appropriate patient selection mechanical circulatory support (MCS) application. In this regard, results most trials or meta-analyses were neut...

AIMS To investigate skeletal muscle in patients with chronic heart failure and controls, and relate skeletal muscle variables to functional class, exercise capacity, central haemodynamics, muscle strength and medical treatment. METHODS Biopsy from the lateral vastus muscle was obtained in 43 patients and 20 controls. Right sided heart catheterization was performed in 19 patients and maximal e...

A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was pers...

The activity of phosphorylase in muscle appears to regulate glycogenolysis (1, 2). The enzyme has been found to exist in two forms, a and b (3-5). Phosphorylase b is active only in the presence of adenosine 5’-monophosphate, whereas phosphorylase a is active in the absence of the nucleotide. Epinephrine and other catecholamines are known to increase phosphorylase activity by accelerating conver...

INTRODUCTION We evaluate an innovative device consisting of an enteral feeding tube equipped with a photoplethysmography (PPG) sensor in contact with the duodenal mucosa. This study aims to determine if the PPG signal, composed of a continuous (PDC) and a pulsatile part (PAC), is a reliable method to assess gut perfusion in a porcine model of septic shock. METHOD Fourteen piglets were anesthe...