Cryptococcal meningoencephalitis is a rapidly lethal infection in immunocompromised patients. Induction regimens are usually administered for 2 weeks. The shortest effective period of induction therapy with liposomal amphotericin B (LAMB) is unknown. The pharmacodynamics of LAMB were studied in murine and rabbit models of cryptococcal meningoencephalitis. The concentrations of LAMB in the plasm...

LamB protein is involved in the transport of maltose across the outer membrane and constitutes the receptor for phage lambda. In this study we characterized six previously described anti-LamB monoclonal antibodies (mAbs). Four of these, the E-mAbs, recognized determinants that were exposed at the cell surface, whereas the other two, the I-mAbs, recognized determinants which were not exposed. Co...

Four Aspergillus nidulans genes are known to be under the control of the trans-acting regulatory gene amdR. We describe the isolation and initial characterization of one of these amdR-regulated genes, lamA. The lam locus, however, was found to consist of two divergently transcribed genes, the lamA gene, and a new gene, also under amdR control, which we have designated lamB. Using recombinant DN...

The purpose of this study was to identify and compare the different evaluations made by the agents at either end of the lamb meat chain, i.e. producers and consumers, in relation to the parameters that consumers use when purchasing lamb meat and the factors that affect the production of quality lamb meat. In addition, consumer segments that can be targeted for action by the different agents in ...

B13, one of the immunodominant antigens of Trypanosoma cruzi, is composed of repeats of a 12-amino-acid motif. Using synthetic peptides, the sequence FGQAAAGDK was previously shown to contain the B13 immunodominant epitope recognized by chagasic patients sera. To investigate the effects of neighboring sequences in the immunodominance, we tested serum recognition of two B13 sequences fused to La...

Cumulative lifetime (five lamb crops) lamb production and wool production of 681 ewes were evaluated in this study. Lamb production and wool production from each ewe at the end of age 2, 3, 4, 5, and 6 yr were added to the previous year's production and analyzed within age of ewe. If a ewe failed to lamb, died, or was culled, it received a zero for that year and subsequent years. Main effects i...

The experiment measured lamb responses to supplementation of the pregnant ewe diet with vitamin E above requirement. Crossbred ewes were mated with either Suffolk or Texel rams. Twin-bearing ewes were randomly allocated (approximately 21 months of age at allocation) to one of four treatment groups (20 ewes per group, 10 mated with Suffolk and 10 with Texel rams). Treatments imposed were 50, 100...

Time reversal active sensing using Lamb waves is investigated for health monitoring of a composite structure. In the present work experiments were conducted on a glass/epoxy composite plates to study the time reversal behavior of A0 and S0 Lamb wave modes. PZT wafer sensors were surface bonded to the structure for generation and reception of the Lamb wave modes. Time reversal experiments were f...

The mathematical and physical properties of the Lamb vector divergence are explored. Toward this aim, the instantaneous and mean dynamics of the Lamb vector divergence are examined in several analytic and turbulent flow examples relative to its capacity to identify and characterize spatially localized motions having a distinct capacity to effect a time rate of change of momentum. In this contex...

Brindley, D. N. & Bowley, M. (1975) Biochem. J. 148,461-469 Fallon,H. J.,Banvick, J.,Lamb,R.G. &vandenBosch,H.(1975)J. LipidRes. 16,107-115 Lamb, R. G. & Fallon, H. J. (1974~) Biochim. Biophys. Actu 348, 166178 Lamb, R. G. & Fallon, H. J. (19746) Biochim. Biophys. Actu 348, 179-188 Lamb. R. G.. Wood, C. K., Guzelian, P. S. & Fallon, H. J. (1976) Fed. Proc. Fed. Am. SOC. Exp. Biol. 35,746 Lamb, ...