نتایج جستجو برای: lamotrigine monotherapy
تعداد نتایج: 16820 فیلتر نتایج به سال:
AIM To ascertain present United Kingdom (UK) management processes for epilepsy in older people. METHOD This was a general practice notes review of people being treated for epilepsy 60 years and over. RESULTS The cohort of 110 was from six practices. Seizure frequency in older people with epilepsy appears lower than in general; 75% are seizure free. This compares with 40-60% of people in oth...
PURPOSE Long-term therapy with antiepileptic drugs (AEDs) has been associated with metabolic consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy. We compared the long-term effects of monotherapy using different categories of AEDs on markers of vascular risk and the atherosclerotic process. METHODS One hundred sixty adult patients who were receiving AED m...
INTRODUCTION Lamotrigine is widely used for mood disorders including bipolar disorder and major depression, but its therapeutic levels have yet to be determined. This study was conducted to investigate the hypothesis that lamotrigine may have a therapeutic window for mood disorders. METHODS 25 patients with mood disorders received lamotrigine for more than one year during which time plasma la...
Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed model.
The purpose of this study was to estimate the effect sizes of drug interactions on plasma olanzapine concentrations while adjusting for potentially confounding factors such as smoking. The estimation was performed by using a mixed model, data from a series of previously published studies of lamotrigine, oxcarbazepine, topiramate, and mirtazapine, and unpublished data from patients under clinica...
OBJECTIVE To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy. METHODS Systematic review of relevant articles published between January 1985 and June 2007. RESULTS It is highly probable that intrauterine first-trimester valproate (VPA) exposure has higher risk of major congenital malformations (MCMs) compared to carbamazepine and ...
Introduction: Lamotrigine is an anti-epileptic drug indicated for the treatment of bipolar disorder and recurrent depressive disorders. Its efficacy has been demonstrated. However, its use may be limited by risk severe, life-threatening allergic reactions. Objectives And Methods: We report hereafter clinical case a patient suffering from depression treated with lamotrigine which induced skin al...
Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...
background: central post-stroke pain (cpsp) is a distressing pain syndrome, sometimes become refractory to the conventional pain managements. anticonvulsants have been used to alleviate different central pains. lamotrigine is a novel anticonvulsant and its proper dosage and its efficacy have not been well studied yet. the aim of this study was to evaluate the effect of 100 mg lamotrigine on ref...
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine (5-HT)3 receptors in NCB-20 neuroblastoma cells. Co-application of lamotrigine (1~300 µM) resulted in a concentration-dependent reduction in peak amplitude o...
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