OBJECTIVE (1) To investigate the incidence of laryngeal involvement in a large series of patients with pemphigus vulgaris, using endoscopic examination, (2) to describe the lesions, and (3) to establish a classification of laryngeal involvement in pemphigus vulgaris based on the location of the lesions. STUDY DESIGN Prospective study. METHODS A total of 40 sequentially treated pemphigus vul...

OBJECTIVES This report provides a detailed knowledge base of individual subject laryngeal cartilage dimensions across multiple species to assist researchers in creating subject-specific biomechanical laryngeal models. METHODS The raw data from previous laryngeal cartilage studies were grouped by species (for human, canine, and ovine) and by cartilage (arytenoid, thyroid, and cricoid) by means...

MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further, Introducing RB cDNA without 3'UTR abrogated miR-106...

Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm

Sarcomas account for a very small percentage of the head and neck malignancies in adults Laryngeal sarcomas represent 1% of all laryngeal malignancies. Chondrosarcoma is the most common laryngeal sarcoma, and originates mostly from the cricoid cartilage. Less than 3% of all cervicocephalic rhabdomyosarcomas is located in the larynx and laryngeal rhabdomyosarcoma is characterized by less aggresi...

The simple reaction time paradigm, incorporating a variable foreperiod, was used to investigate relative contributions of the respiratory and laryngeal systems to mild and severe stutterers' prolonged acoustic laryngeal reaction time (LRT) values. Prephonatory kinematic data were analyzed in terms of frequency of initiation, timing, and organization of events executed to attain the functional p...

INTRODUCTION A non-recurrent course is a rare anatomic variation of the inferior laryngeal nerve (ILN). Bilateral extra-laryngeal bifurcation of the ILN seldom occurs before its laryngeal entry. Anastomosis between the ILN and cervical sympathetic chain is another rare anatomic feature. The prevalence of extra-laryngeal branching of the non-recurrent nerve is unknown. We present an example of t...

The relative contributions of innervation and androgen to three muscle fiber properties-twitch type, size, and number-were examined in the sexually dimorphic, androgensensitive laryngeal muscle of Xenopus laevis. In adults, the muscle contains all fast-twitch fibers in males and fastand slow-twitch fibers in females; laryngeal muscle fibers are larger and more numerous in males than in females....

Objectives/Hypothesis. To determine if laryngopharyngeal reflux alters mucin gene expression in laryngeal mucosa. Methods. In situ hybridization was employed to study the expression of the 8 well-characterised mucin genes MUC1-4, 5AC, 5B, 6, and 7 in reflux laryngeal mucosa from laryngeal ventricles, posterior commissures, and vocal folds compared to control/normal laryngeal mucosa. Results. MU...

OBJECTIVES The larynx is susceptible to irradiation, which causes significant vocal fold (VF) edema and dehydration shortly after radiotherapy for head and neck cancers. However little is known about radiation-induced damage to VF liquid homeostasis. To evaluate the effects of irradiation on VF hydration and lubrication, we investigated changes in water transporters (aquaporins [AQPs]) and muci...