the boundary of a system. The characteristics of the threshold bared of insulation. The effects of stimulation were tested gradients suggest that, with intensities on the order of 25 pa, the for 5 days with the electrode at each lateral hypothalamic effective spread of current from small monopolar electrodes may site; each week the electrodes were moved approximately be as little as l/8 mm. The...

Estradiol and other hormones are thought to be critical for the onset, but not maintenance, of maternal behavior in rats. Maternal behavior is instead maintained postpartum by tactile stimulation that dams receive during interactions with pups, and many neural sites implicated in the control of maternal behavior show elevated c-fos activity in response to this stimulation. Many of these sites a...

Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric disorders, including those characterized by the presence of repetitive behaviors. We developed an optogenetic approach to block repetitive, compulsive behavior in a mouse model in which deletion of the synaptic scaffolding gene, Sapap3, results in excessive grooming. With a delay-conditioning task, we identif...

Previous studies have attributed multiple diverse roles to the posterior superior temporal cortex (STC), both visually driven and cognitive, including part of the default mode network (DMN). Here, we demonstrate a unifying property across this multimodal region. Specifically, the lateral intermediate (LIM) portion of STC showed an unexpected feature: a progressively decreasing fMRI response to ...

Research was undertaken in an attempt to clarify the relationship between stimulus-bound eating and self-deprivation produced by electrical stimulation of the lateral hypothalamus. It was hypothesized that if these two phenomena are mediated through a common population of feeding-related neurons, a significant correlation should be observed between these two behaviors. No significant relationsh...

Modulation of activity in the left temporoparietal area (LTA) by 10 Hz repetitive transcranial magnetic stimulation (rTMS) results in a transient reduction of tinnitus. We aimed to replicate these results and test whether transcranial direct current stimulation (tDCS) of LTA could yield similar effect. Patients with tinnitus underwent six different types of stimulation in a random order: 10-Hz ...