The objective of this study was to establish the role of apoA-IV, ABCA1, and LCAT in the biogenesis of apoA-IV-containing HDL (HDL-A-IV) using different mouse models. Adenovirus-mediated gene transfer of apoA-IV in apoA-I(-/-) mice did not change plasma lipid levels. ApoA-IV floated in the HDL2/HDL3 region, promoted the formation of spherical HDL particles as determined by electron microscopy, ...

Apolipoprotein E (apoE) enters the plasma as a component of discoidal HDL and is subsequently incorporated into spherical HDL, most of which contain apoE as the sole apolipoprotein. This study investigates the regulation, origins, and structure of spherical, apoE-containing HDLs and their remodeling by cholesteryl ester transfer protein (CETP). When the ability of discoidal reconstituted high d...

The mechanism(s) through which smoking influences the progression of atherosclerosis is poorly understood. Recent evidence suggests that oxidants present in the gas phase of cigarette smoke are involved. We exposed human plasma to the filtered gas phase of cigarette smoke to assess its effects on plasma components involved in the antiatherogenic reverse cholesterol transport pathway. In our mod...

Epidemiological data clearly show the existence of a strong inverse correlation between plasma high-density lipoprotein cholesterol (HDL-C) concentrations and the incidence of coronary heart disease. This relation is explained by a number of atheroprotective properties of HDL, first of all the ability to promote macrophage cholesterol transport. HDL are highly heterogeneous and are continuously...

BACKGROUND The serum concentration of high-density lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. In this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (LCAT) gene polymorphism rs5923 on LCAT enzyme activity and serum HDL-C concentration. METHODS The study...

Abstract Objective Research supports the relevance of therapeutic alliance (TA) between patients and physical therapists on outcomes, but impact TA during routine therapist practice has not been quantified. The primary objective this study was to examine relationship assessed a therapy episode care for with low back pain functional outcome at conclusion care. secondary psychometric properties W...

Carbon emission reduction in agriculture is an important link to achieving green agricultural development and a rural ecological environment, Low-Carbon Agricultural Technology (LCAT) of farmers means achieve carbon agriculture. Based on data obtained from survey 540 Sichuan province 2021, the Tobit model was used empirically analyze effect trust farmers’ LCAT adoption. The results show that (1...

The enzyme 1ecithin:cholesterol acyl transferase has been measured both in total plasma and in the fraction of plasma from which very low and low density lipoproteins have been removed by ultracentrifugation. The correlation between the activity of the enzyme and the free cholesterol concentration was positive in whole plasma and negative in apoB-deficient plasma. On the other hand, the positiv...

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT-OEGs with a range of functional...