OBJECTIVE • To determine if the RENAL nephrometry score is associated with urine leak after partial nephrectomy for tumours ≤ 7 cm. PATIENTS AND METHODS • Thirty-one patients who developed urine leak after partial nephrectomy between 1998 and 2006 were identified. Each patient was individually matched (1 : 4 by age, gender and surgery date) to 124 patients who had undergone partial nephrectom...

Increased diastolic SR Ca2+ leak (J(leak)) could depress contractility in heart failure, but there are conflicting reports regarding the J(leak) magnitude even in normal, intact myocytes. We have developed a novel approach to measure SR Ca2+ leak in intact, isolated ventricular myocytes. After stimulation, myocytes were exposed to 0 Na+, 0 Ca2+ solution +/-1 mmol/L tetracaine (to block resting ...

This paper proposes a new framework for leak diagnosis in pipelines using leak-augmented scalograms and deep learning. Acoustic emission (AE) scalogram images obtained from the continuous wavelet transform have been useful pipeline health diagnosis, particularly when combined with However, background noise has significant impact on AE signals, which can reduce accuracy of identification classif...

A 69-year-old man, with a permanent pacemaker (PM) and a tricuspid bioprosthesis implanted 6 years ago, was admitted due to gradual exacerbation of heart failure symptoms to NYHA class III. Transthoracic (TTE) and transesophageal (TEE) echocardiography revealed proper function of bioprosthesis leaflets accompanied by the presence of severe paravalvular leak (PVL) with the PM lead crossing its c...

SMCT1 is a Na-coupled cotransporter of short chain monocarboxylates, which is expressed in the apical membrane of diverse epithelia such as colon, renal cortex, and thyroid. We previously reported that SMCT1 cotransport was reduced by extracellular Cl(-) replacement with cyclamate(-) and that the protein exhibited an ostensible anionic leak current. In this paper, we have revisited the interact...

Active modulation of ions and molecules via field-effect gating in nanofluidic channels is a crucial technology for various promising applications such as DNA sequencing, drug delivery, desalination, and energy conversion. Developing a rapid and facile fabrication method for ionic field-effect transistors (FET) over a large area may offer exciting opportunities for both fundamental research and...

AIM To share the results of conventional surgery in rhinorrhea and the contribution of computerized tomography (CT) cisternography to determination of the site of cerebrospinal fluid (CSF) leak. MATERIAL AND METHODS Twelve cases treated for spontaneous rhinorrhea were included in this study. All the cases underwent cranial CT and magnetic resonance imaging (MRI). CT cisternography was perform...

RATIONALE Numerous types of flap coverage have been reported to prevent or to repair bronchopleural fistulas. Most of the flaps were harvested from chest area. However, these pedicled flaps might not be optimal for the patient who has undergone previous radiotherapy on pulmonary parenchyma because the pedicle artery of the flap might have been injured by irradiation. Therefore, an alternative f...

Background: Esophagojejunal anastomotic leak (EJAL) is a serious and often life-threatening complication following total gastrectomy. There no standard management strategy, the optimal approach remains controversial. Whilst non-operative (with or without percutaneous drainage), endoscopic (stents, clips, vacuum devices) preferred initial management, there subset of EJAL patients that require op...

Excessive calcium influx is important in the irreversible injury of cardiac myocytes and other cell types. The mechanism is unknown, but possibilities include L-type channels, Na(+)-Ca2+ exchange, sarcolemmal (SL) defects, and calcium leak channels. In this study, metabolic inhibition was used to induce ATP depletion and augmented calcium influx in cultured cardiac myocytes. Inhibition of the L...