BACKGROUND Dilated cardiomyopathy is characterized by left ventricular dilatation and dysfunction. Inflammation and adverse remodeling of the extracellular matrix may be involved in the pathogenesis. Statins reduce levels of low density lipoprotein cholesterol, but may also attenuate inflammation and affect matrix remodeling. We hypothesized that treatment with rosuvastatin would reduce or even...

background: left ventricular (lv) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of lv function. we sought to assess the impact of chronic pure mitral regurgitation (mr) on the torsional mechanics of the left human ventricle using tissue doppler imaging. methods: nineteen severe mr patients with a normal lv ejection fraction and 16 non-...

The prognostic significance of left ventricular ejection fraction measurements obtained at the bedside was assessed in 171 patients as soon as possible after acute myocardial infarction. Ejection fraction was measured with a radionuclide first pass portable probe method within a mean of 24 hours of the onset of major symptoms. The results were related prospectively to the subsequent incidence o...

To determine the relationship of left ventricular function and ventricular tachycardia, 48 hour ECG monitoring and technetium-99m gated equilibrium radionuclide angiography were performed in 84 consecutive patients with hypertrophic cardiomyopathy and sinus rhythm. Measurements of ejection fraction (EF), peak ejection rate (PER, edv/s), peak filling rate (PFR, edv/s) and time to peak filling ra...

t1 TITLE (include Security Classi kation) REST AND EXERCISE LEFT VENTRICULAR EJECTION FRACTION BEFORE AND AFTER THERAPY IN YOUNG ADULTS WITH HYPERTHYROIDISM AND HYPOTHYROIDISM 12. PERSONAL AUTHOR(S) R.C. SMALLRIDGE, M. H. GOLDMAN, K.RAINES, S. JONES, AND D.V. NOSTRAND 137 TYPE OF REPORT ' Ib TIME COVERED 14 DATE OF REPORT (Year. Month, Day) 15 PAGE COUNT Manuscript I FROM TO 16 SUPPLEMENTARY NO...

To determine whether endurance exercise training can improve left ventricular systolic function in older men, 10 healthy sedentary men (64 +/- 3 years old; mean +/- SD) were studied. Training consisted of endurance exercise 4 +/- 0.3 days per week for 11.8 +/- 2.5 months at a progressively increasing intensity of 60-80% of maximal O2 uptake (Vo2max) with additional brief bouts of exercise equal...

Beneficial effects of recombinant human GH on cardiac function have been reported in humans with GH deficiency and in patients with idiopathic dilated cardiomyopathy. No randomized controlled trial has been performed on the effects of recombinant human GH on cardiac function in patients with ischemic cardiac failure. We therefore randomly assigned 22 patients with ischemic cardiac failure (left...

The effects of preload augmentation on left ventricular output (Frank-Starling mechanism), ejection fraction, and the relationship between pulmonary wedge pressure and end-diastolic volume were studied in 15 patients immediately after myocardial revascularization. The patients were studied under morphine sulfate anesthesia with the chest temporarily closed. Sequential measurements of radionucli...