PURPOSE During an ethylnitrosourea (ENU) mutagenesis screening, mice were tested for the occurrence of dominant cataracts. The purpose of the study was morphologic description, mapping of the mutant gene, and characterization of the underlying molecular lesion in a particular mutant, Aey7. METHODS Isolated lenses were photographed and histologic sections of the eye were analyzed according to ...

Aims: The pathway of subarachnoid hemorrhaged blood into the eye in Terson’s syndrome has not been definitively determined. We present our findings in a patient with Terson’s syndrome that provided clues on how the subarachnoid hemorrhaged blood entered the eye. Presentation of Case: A 47-year-old man visited our department three months after a subarachnoid hemorrhage. His visual acuity was han...

PURPOSE To evaluate the visual outcome of combined phacoemulsification, intraocular lens implantation, and vitrectomy for macula-sparing rhegmatogenous retinal detachment. METHODS The results of combined vitrectomy with cataract extraction were retrospectively analyzed in patients with preexisting cataracts and new-onset rhegmatogenous retinal detachment. To qualify, patients must also have h...

We investigated the location and severity of lens opacities and epithelial alterations following ultraviolet-B (UVB) irradiation in vivo, using Brown Norway rats. A group of 9 rats received 65 mJ/cm2 UVB irradiation from overhead lamps every 6 days. Lens changes were documented and evaluated by an anterior eye segment analysis system. Lens epithelial cells were examined postmortem in flat prepa...

PURPOSE To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHODS The amount of light scattered by donor lenses (n = 15; age range, 43 to 82...

Type 2 diabetes (T2D) generally follows prediabetes (PD) conditions such as impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Although studies reported an association of IGT or IFG with cataract, the experimental basis for PD associated cataract is not known. Hence, we evaluated neonatal streptozotocin (nSTZ) induced rat model to study PD associated cataractogenesis by inj...

PURPOSE Although diabetic retinopathy (DR) is clinically diagnosed based on vascular pathology, diabetic patients with angiographically normal retinas have been found to exhibit subtle defects in vision. This has led to the theory that diabetes-associated metabolic abnormalities directly impair neural retinal function before the development of vasculopathy, thereby resulting in visual deficits....

BACKGROUND The opacification of the intraocular lens (IOL) can cause significant visual deterioration. It is known that opacity of hydrophobic acrylic IOLs is rare. We report 2 cases of reversible optic opacification of hydrophobic acrylic intraocular lenses (Tecnis ZCB00, Abbott), observed within 2 months after uneventful cataract surgery. CASE PRESENTATION Case 1: Uneventful cataract surger...