Obesity causes hyperleptinemia. We have previously shown that D2 receptor-mediated inhibition of ventral tegmental area (VTA) dopaminergic neurons is attenuated in diet-induced mice with obesity. Consequently, we hypothesized that high concentrations of serum leptin during obesity might modulate D2 receptor-mediated effects on VTA dopaminergic neurons. To investigate our hypothesis, we examined...

Introduction: Leptin and Ghrelin are hormones that have been discovered in the last decade and were shown to be involved in appetite and metabolism regulation and body weight. Thyroid hormones are also    involved in general metabolism and changes in their circulating levels bring about changes in appetite and body weight. Results of animal and human studies regarding Leptinlevel and its re...

the adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (cad). the inflammatory enzyme, myeloperoxidase (mpo) also has an important role in the pathogenesis of cad. association of the adipokines with mpo remains to be resolved in patients with cad. in this case-control study, 100 patients with cad and 100 control subjects were appropriately r...

Leptin is a hormone that is secreted by fat cells and has roles in body weight regulation, glucose metabolism, reproduction, and other neuroendocrine functions. The purpose of this study was to determine whether the secretagogues, insulin, glucose, and pyruvate, enhance leptin secretion by increasing leptin synthesis, or whether these secretagogues stimulate the quantal release of a stored cyto...

introduction: leptin, secreted from adipose tissue may have some correlation with coronary artery disease according to some reports in literature. the mean concentration of plasma leptin in patients with normal and abnormal myocardial perfusion imaging (mpi) and relation of leptin levels, independently to abnormality in mpi after correction for body mass index (bmi) was evaluated. methods: as a...

Abstract Background and Aims Chronic kidney disease (CKD) is a major health problem associated with faltering growth, which complex process, where anorexia, inadequate oral intake in addition to disturbed body metabolism play significant role. Leptin, the anorexigenic hormone that's secreted by fat tissue, affect appetite, & hence, aids weigh loss growth. The present study evaluated serum l...

To assess the role of the human kidney in leptin metabolism, we measured renal leptin net balance and urinary leptin excretion in 16 normal postabsorptive volunteers with varying degrees of obesity. Arterial leptin concentrations (11.6 ± 2.7 ng/ml) significantly exceeded renal vein concentrations (10.3 ± 2.5 ng/ml, P < 0.001). Renal leptin fractional extraction averaged 13.1 ± 1.1%, and renal l...