BACKGROUND To provide guidance for clinical practice on preferred standard palliative radiotherapy (RT) of different sites of metastasis for breast cancer patients based on current published evidence complemented by expert opinion. METHODS The breast cancer expert panel of the German Society for Radiation Oncology (DEGRO) and members of the Working Party of Gynecologic Oncology (AGO) Breast C...

It is well known that head injuries with a linear skull fracture in infancy sometimes cause a growing skull fracture') with or with out a leptomeningeal cyst.') This condition, however, is mainly located in the supratentorial portion of the cranium. Leptomeningeal cysts in the posterior fossa are rare, and to our knowledge, there have been only four cases reported in the literature. The leptome...

Once considered the culmination of metastatic disease and a marker of the terminal end of a patient’s experience with cancer, leptomeningeal disease (LMD), also known as neoplastic meningitis and carcinomatous meningitis, has become an increasingly frequent complication of cancers (Bomgaars, Chamberlain, Poplack, & Blaney, 2002). LMD may even occur when a patient is in systemic remission. As pa...

Medulloblastoma is the most common malignant brain tumor in children. Current multimodal treatment regimens consisting of surgery, radiation, and chemotherapy, as well as advances in imaging, have contributed to increased survival rates over the past decade. Patients with newly diagnosed disease demonstrate survival rates that range from less than 50% to greater than 90%, depending on the molec...

•Leptomeningeal disease occurs more commonly in BRCA-mutated ovarian cancer.•A clinically significant dose of olaprib is able to penetrate the leptomeninges.•Leptomeningeal metastases in a BRCA-mutated ovarian cancer responded to olaparib.

A 60-year-old male was diagnosed with T3, N3, M1b epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma. Five months later he developed significant headaches, weakness and numbness of the left leg, and unsteadiness of gait. Magnetic resonance imaging (MRI) brain demonstrated subtle gyral enhancement indicative of early leptomeningeal infiltration. He was commenced on second-line er...

Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer. Investigation of intrathecal (IT) trastuzumab for leptomeningeal carcinomatosis is currently underway; however, there has been no consensus. We report on two cases of human epidermal growth factor receptor 2 positive (HER2+) breast cancer following IT trastuzumab for leptomeningeal carcinomatosis. The first pati...

Medulloblastomas aremalignant brain tumors that arise in the cerebellum in children and disseminate via the cerebrospinal fluid to the leptomeningeal spaces of the brain and spinal cord. Challenged by the poor prognosis for patients withmetastatic dissemination, pediatric oncologists have developed aggressive treatment protocols, combining surgery, craniospinal radiation, and high-dose chemothe...

BACKGROUND Glioblastoma multiforme infrequently metastasizes to the leptomeninges and even more rarely to the spinal cord. Moreover, very few patients with intracranial glioblastoma develop symptoms from spinal dissemination, with most patients not surviving long enough for spinal disease to become clinically evident. CASE REPORT We present a rare case of symptomatic diffuse spinal leptomenin...