Twenty-two patients with primary myeurinary hemosiderin. The defects of lofibrosis and myeloid metaplasia the red cell membrane, as evidenced (MMM) and ten patients with MMM by acid and sucrose lysis tests, were secondary to carcinoma were studied limited to those with primary MMM and for the relationship of MMM to “PNHoccurred in 54#{176}/o of the cases. Another like defect.” Laboratory measur...

Tetracyclines exhibit significant anti-inflammatory properties, inhibit matrix metalloproteinases (MMPs), and are protective in models of ischemia-reperfusion injury (IRI). Both inflammatory cascades and MMP activation have been demonstrated to modulate microvascular permeability. Because increased microvascular permeability occurs during IRI in a variety of organ systems including the kidney, ...

Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one with complete deficiency were identified. Fami...

The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed...

The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infections, NTM can cause diffused infections as well as extrapulmonary infections in every organ, such as bone marrow, s...

We report a familiar syndrome of recurrent heterogeneous infectious diseases, caused by bacteria, fungi, and viruses, which has as its only detectable defect the lack of CD53 antigen expression in neutrophils. All other assays ruled out known causes of recurrent infectious diseases due to either leukocyte adhesion or phagocytosis defects. CD53 belongs to the transmembrane-4 superfamily of prote...

The leukocyte integrin LFA-1 (CD1 la /CD 18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and sho...

background: protective immune responses induced in the majority of people infected with mycobacterium tuberculosis enable them to control tb infection. objective: the aim of this study was to investigate cd56 and cd16 positive peripheral blood mononu-clear cells (pbmcs) and leukocyte subsets from multi-drug resistant pulmonary tuber-culosis (mdr-tb), and compare them with nonresistant (nr) tb p...

conclusions systemic arterial leukocyte filtration reduces the intubation time but has no other beneficial effect on the outcome of patients undergoing cabg or valve surgery. results the postoperative intubation time was significantly shorter in patients with leukocyte filters (0.014). there was no significant difference between two groups regarding other outcome relatedvariables. patients and ...