A man in his 80s with IgG kappa and free light chain multiple myeloma was admitted to hospital several weeks’ history of falls cognitive decline. Magnetic resonance imaging the brain demonstrated bilateral lesions corona radiata, centrum semiovale, corpus callosum. The suspicion for progressive multifocal leukoencephalopathy raised due ongoing use lenalidomide myeloma. diagnostic lumbar punctur...

Many mammalian AQPs, including AQP1, AQP2, AQP4, AQP5 and AQP8, function primarily as bidirectional water-selective transporters. Cells expressing AQPs on their plasma membrane have an ~5- to 50-fold higher osmotic water permeability than membranes that do not. Water transport through single-file pores poses a biophysical limitation on the efficiency with which AQPs can transport water, so that...