Fast dissolving film of levocetrizine dihydrochloride were prepared by solvent casting method by using Maltodextrin & HPMC E15 as the main film forming polymers.To decrease the disintegration time,concentration of maltodextrin & HPMC E15 were optimized be using 2 factorial design. Disintegration time, drug release pattern, mouth dissolving time and content uniformity were also evaluated. Compat...

The present research work was to design and develop an optimized melt-in-mouth tablet dosage form of an anti-allergic drug, Levocetirizine dihydrochloride by using sublimation technology. A total number of thirteen formulations were prepared as per the standard experimental design protocol using Design Expert Software (Version 7.1.6, StatEase Inc, Minneapolis, MN). Independent variables such as...

H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these drugs have been considered effective in controlling sneezing, rhinorrhea and itching, though they have not been regarded as particularly effective in application to nasal obstruction. The most recent studies, involving second-generation H1 antihistamines (desloratadine, fexofenadin...

In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual doses, they potentially cause sedation and impair cognitive function and psychomotor performance. These medications, some of which have been in use for...

Importance of compounds investigated (loratadine, desloratadine, cetirizine dihydrochloride, levocetirizinedihydrochloride) in contemporary pharmacy causes necessity of finding the fast and easy method for their identification. The aim of this work is to find the best way of visualization of chromatographic spots in qualitative determination of compounds investigated during analysis by thin lay...

Second-generation antihistamines are widely prescribed for the control of symptoms of allergic inflammation such as itchy hives, coryza, and itchy eyes. In rare circumstances, these drugs might provoke allergic inflammation. Hypersensitivity to bepotastine besilate, a second-generation antihistamine has never been reported. A 17-year-old schoolgirl, whose paroxysmal itchy hives had been control...