Purpose: Currently, no clinical data exists comparing ceftaroline to a “respiratory” fluoroquinolone in patients with community-acquired bacterial pneumonia (CABP). The purpose of this study was to compare time-kill assays of ceftaroline and levofloxacin against clinical isolates of Staphylococcus aureus using sera from hospitalized patients with a diagnosis CABP. Methods: A total of 12 patient...

Deep eutectic solvents (DES) are potential ecofriendly surfactants for the preparation of materials. In this study, both molecularly imprinted polymers (MIPs) and mesoporous siliceous materials (MSMs) were modified by betaine-based DES. Six materials were employed as solid phase extraction (SPE) adsorbents for the rapid purification of levofloxacin. The DES-based materials showed better selecti...

Three isolates of Streptococcus agalactiae, recovered from residents of the metropolitan area of Rio de Janeiro with significant bacteriuria, were found to be resistant to levofloxacin. Determination of the minimal inhibitory concentration (MIC) confirmed one isolate as intermediate and two as resistant to levofloxacin. No reduction in levofloxacin MIC was observed with reserpine, indicating th...

The cyclic changes of menstrual cycle alter the pharmacokinetics of levofloxacin. The effect of follicular and luteal phase on levofloxacin pharmacokinetics was studied in 15 healthy female volunteers taking a single dose of 500mg tablet on day 10 (follicular phase) and day 21 (luteal phase ). Levofloxacin levels in saliva samples at different time points were estimated by HPLC. Follicular phas...

The safety and pharmacokinetics of once-daily oral levofloxacin in 16 healthy male volunteers were investigated in a randomized, double-blind, placebo-controlled study. Subjects were randomly assigned to the treatment (n = 10) or placebo group (n = 6). In study period 1, 750 mg of levofloxacin or a placebo was administered orally as a single dose on day 1, followed by a washout period on days 2...

BACKGROUND Limited prospective data are available for elderly patients with community-acquired pneumonia (CAP). This study aimed to determine the efficacy and safety of moxifloxacin versus that of levofloxacin for the treatment of CAP in hospitalized elderly patients (age, > or = 65 years). METHODS We conducted a prospective, double-blind, randomized, controlled trial. Eligible patients were ...

Fluoroquinolones are a group of antibiotics widely used because of their broad spectrum activity against both Grampositive and Gram-negative bacteria. In this study, ciprofloxacin and levofloxacin were administered to rats at therapeutic doses to evaluate their effects on plasma arylesterase activity, as well as, on hepatic advanced oxidized protein products (AOPPs) and malondialdehyde (MDA) le...

Fluoroquinolones are widely used in the management of infectious diseases, and are generally safe and well tolerated. However, immediate hypersensitivity reactions, including anaphylactic reactions, have been reported. We present here a case of anaphylactic shock in a 26-year-old man following intravenous levofloxacin administration. Skin tests confirmed an immediate hypersensitivity reaction t...