We describe a case of a 67-year-old Caucasian woman with an early, moderately-differentiated adenocarcinoma of the endometrium. A levonorgestrel-releasing intrauterine system was inserted, which she tolerated well. A full D&C, following removal of the device, was performed after 9 months, confirming absence of tumoral tissue. Examination after 24 months showed a very thin endometrium, indicatin...

-the; A major reduction in the number of unwanted pregnancies and pregnancy terminations could be achieved if an effective method of emergency pregnancy interception (postcoital contraception) was readily available to women. This policy stakmnt describes a method which is the Yuzpe 2 + 2 regimen; the use of two tablets of estradioI/levonorgestrel, with an antiemetic, followed by a second identi...

To the Editor: Numerous drugs have been implicated as possible causes of lichenoid drug eruptions (LDEs). We describe a case of an LDE secondary to placement of a levonorgestrel-releasing intrauterine system (IUS). A 28-year-old woman presented with an extensive pruritic rash of 2 months’ duration. She reported that it began on the wrists; progressed inward to involve the trunk; and then became...

Background: Abnormal uterine bleeding (AUB), is defined as a change in any or combination of frequency, duration, amount bleeding, common gynecological complaint that affects 10‑30% reproductive‑aged women and constitute about one‑third all outpatient visits. Mirena hormonal intrauterine device classified long-acting reversible contraceptive method. Women with heavy menstrual blood loss, the LNG...

BACKGROUND Drospirenone/ethinyl-estradiol is an oral contraceptive (OC) that possesses unique antimineralocorticoid activity. It is conjectured that drospirenone, taken alone or concomitantly with spironolactone, may be associated with an increased risk of hyperkalemia. METHODS A retrospective cohort study was conducted evaluating women between 18-46 years of age in the Lifelink™ Health Plan ...

Oral contraceptive (OC) use is associated with an increased risk of venous thromboembolism. Previous data reported higher thrombotic risk in women using third-generation combined OC than in those using second generation OC. The difference could be explained by differential effects of progestagens on plasma sensitivity to activated protein C (APC). The main purpose of this cross-sectional study ...

Dear editor: 1 few years after coming to the market, the first generation of oral contraceptive pills (OCPs) were linked to significant risk of venous thromboembolism (VTE). This increased risk was blamed on the presence of the estrogen-like compounds in these agents. Therefore, the efforts were initiated to decrease the VTE risk of OCPs by lowering the delivered estrogen content by adding prog...

Abstract Background Breastfeeding and postpartum contraception critically influence infant maternal health outcomes. In this pilot study, we explore the effects of timing duration levonorgestrel exposure on milk lipid content to establish baseline data for future research. Methods This sub-study recruited a balanced convenience sample from 259 participants enrolled in parent randomized controll...