Since Mendel’s time, most genes have been identified by the effects mutations (including knockouts) have on the morphology, physiology, or behavior of individuals. Thus, almost by definition, there could be no ‘‘mutant genes without phenotypes.’’ In the molecular era, however, it has become possible to identify genes from DNA sequences. This alternative path to gene discovery has already led to...

The aim of this study was to assess the usefulness of the inbred rat model for studies of genetic influences on skeletal fragility. We characterized bone mass, geometry, and skeletal biomechanics in 11 inbred strains of rats. This study showed that considerable variation exists in bone structure, areal bone mineral density (aBMD), and fragility phenotypes among inbred strains of rats. Interesti...

Crescentic glomerulonephritis (CRGN) is a major cause of human kidney failure, but the underlying mechanisms are not fully understood. Wistar Kyoto (WKY) rats are uniquely susceptible to CRGN following injection of nephrotoxic serum, whereas Lewis (LEW) rats are resistant. Our previous genetic studies of nephrotoxic nephritis (NTN), a form of CRGN induced by nephrotoxic serum, identified Fcgr3 ...

Numerical study of double-diffusive natural convective heat transfer in a curved cavity filledwith a porous medium has been carried out in the current study. Polar system has beenselected as coordinate system. As a result, all equations have been discredited in r and θdirections. Brinkmann extended Darcy model has been utilized to express fluid flow inporous matrix in the enclosure. Smaller and...