Multiple myeloma (MM) is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow (BM). The progression, from early stages disease as monoclonal gammopathy undetermined significance (MGUS) and smoldering multiple (SMM) to MM occasionally extramedullary disease, drastically affected tumor microenvironment (TME). Soluble factors direct cell–cell interactions r...

1. Clinical History A 41 year-old male presented to his primary care provider for prostate screening. The patient had a history of hypogonadism and low testosterone, as well as a family history of prostate cancer. Physical exam demonstrated significant left scrotal swelling. Palpation of the right testicle was normal. Palpation of the left testicle was limited secondary to scrotal swelling. A s...

The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells were quantified by spectrophotometrically measuring the concentration of crystal violet stain extracted from their nuclei. Cell number was correlate...

conclusions pc-rplnd is one the major operations in the field of urology, which is associated with significant adjunctive surgeries. in appropriate cases, pc-rplnd was associated with good cancer specific survival in tertiary oncology center. results twenty-one patients underwent bilateral pc-rplnd. mean age was 26.3 years (ranged 16 - 47). mean size of retroperitoneal mass after chemotherapy w...

Thirty 18-month-old male F344/DuCrj rats were divided into the following groups: 10 untreated controls; eight vehicle-injected controls; and 12 ethanedimethanesulfonate (EDS)-injected rats. Untreated controls were killed immediately to check for testicular tumor incidence. In rats of the test group, a 75-mg/kg dose of EDS dissolved in dimethyl sulfoxide:water (1:3) was injected i.p. At interval...

Virilization due to hyperandrogenism in women causes male signs and symptoms such as swelling of the clitoris, deepening of the voice, facial hair and increase in body hair. Virilization is caused by less than 0.5% of all ovarian tumors. Here we report a case of virilizing Leydig cell tumor of the left ovary in a 36 year old woman. Misinterpretation of symptoms, conflicting medical information ...