We have provided evidence for a multifaceted antitumor-function of the Toll-like receptor 7 (TLR7) agonist imiquimod, which rapidly recruits plasmacytoid dendritic cells and possibly other immune cells into tumors by inducing the secretion of CCL2 by dermal cells. Imiquimod induces pDC maturation and their conversion into cytolytic killer cells, which are capable of eliminating tumors independe...

A substantial number of enterprises and independent software vendors are adopting a strategy in which software-intensive systems are developed with an open architecture (OA) that may contain open source software (OSS) components or components with open APIs. The emerging challenge is to realize the benefits of openness when components are subject to different copyright or property licenses. In ...

Numerous licenses confuse new participants in the free/open source software (FOSS) world. In this paper, we provide a general introduction to eleven commonly-used FOSS licenses. By applying seven specific considerations that are proposed in our study, developers can identify which license suits their needs best. We further use the above considerations to rank these FOSS licenses, which are Open...

While highly successful in terms of profitable seafood production, salmon ( Salmo salar ) aquaculture may also be a source potential negative environmental externalities. In an attempt to address these challenges through supporting the development new technology, Norwegian government has introduced class licenses labeled as licenses. As result, technological solutions were proposed reduce exter...

The combinatorial clock-proxy auction is analyzed as a selling mechanism of a portion of the “digital dividend” in an European country.We assumed bidders with bounded rationality making their bidding decisions based on a system of recommendation that learns from the environment. The auction outcome when all bidders follow the proposed strategies was compared with the efficient outcome of the au...

The purpose of open source and free software licensing is to permit and encourage the involvement by licensees in improvement, modification, and distribution of the licensed work. This open development model of software development is the unique strength of the open source and free software movement. While the open source and free software licenses already discussed approach open software devel...

To ensure the stable transmission of the genome during vertebrate cell division, the mitotic spindle must attach to a single locus on each chromosome, termed the centromere. The fundamental requirement for faithful centromere inheritance is the controlled deposition of the centromere-specifying histone, CENP-A. However, the regulatory mechanisms that ensure the precise control of CENP-A deposit...