Ferroptosis is a form of cell death caused by iron-dependent lipid peroxidation. Cancer cells increase cystine uptake for the synthesis glutathione (GSH), which used peroxidase 4 to reduce peroxides. Here, we report that deprivation in glioblastoma cells, but not inhibition GSH l-buthionine sulfoximine (BSO), induces ferroptosis. We found decreased protein levels ferritin heavy chain FTH1, wher...

Sensory deprivation sheds light on cortical plasticity mechanisms, but recovery of lost brain function may bear the greatest clinical relevance. Ramoa and colleagues now find that binocular recovery from monocular occlusion can be extraordinarily rapid, independent of protein synthesis, and precise. Reactivation of latent connections may then reverse amblyopia.

The clinical observations of diurnal variation of mood and early morning awakening in depression have been incorporated into established diagnostic systems, as has the seasonal modifier defining winter depression (seasonal affective disorder, SAD). Many circadian rhythms measured in depressive patients are abnormal: earlier in timing, diminished in amplitude, or of greater variability. Whether ...

introduction: barrel cortex of rats is a part of somatosensory cortex, which receives information from facial whiskers. vibrisectomy by sensory deprivation leads to some changes in the barrel cortex, which have been known as experience dependent plasticity. on the other hand, norepinephrine (ne) and locus coeruleus, which is the main source of ne, influenced response properties of cortical barr...