We determined the effects of mono-L-arginine-containing compounds on pial arterioles of anesthetized piglets. A closed cranial window was implanted, and the diameter of one pial arteriole was determined by intravital microscopy. Diameter was determined during application of artificial cerebrospinal fluid containing no drugs and during application of 10-5 10-4, 10-3, and 10-2 M L-arginine (ARG),...

An endogenous digitalis-like substance (DLS) may be involved in the pathogenesis of essential hypertension and pre-eclampsia. The digoxin levels in maternal and cord blood of 504 randomly selected patients were determined. Since none of the patients received digoxin, these levels indicated a crossreacting substance (immunoreactive DLS). DLS levels were significantly higher in the cord blood of ...

Individual substances are the ground of Aristotle’s ontology. Taking a liberal approach to existence, Aristotle accepts among existents entities in such categories other than substance as quality, quantity and relation; and, within each category, individuals and universals. As I will argue, individual substances are ontologically independent from all these other entities, while all other entiti...

Certain people are at risk for using alcohol or other drugs excessively and for developing problems with their use. Their susceptibility might arise from a variety of factors, including their genetic make-up, brain chemistry, family background, personality and other psychological variables, and environmental and sociocultural variables. Moreover, after substance use has become established, ther...

1 Sound frequency-invariant neural coding of a frequency-dependent cue to 1 sound source location 2 3 Running title: Interaural level difference coding 4 5 Heath G. Jones, Andrew D. Brown, Kanthaiah Koka, Jennifer L. Thornton, and Daniel J. 6 Tollin 2 7 8 Neuroscience Training Program, University of Colorado School of Medicine, Aurora, CO 9 80045 10 Department of Physiology & Biophysics, Univer...