Ataxia telangiectasia (ATM), AT like disorder (MRE11), AOA1 (APTX) and AOA2 (SETX) in the UK – variability of the neurological, genetic and cellular phenotypes 19.05-20.00 Jan Hoeijmakers (Netherlands) The link between DNA damage, global and transcription coupled repair and neurodegeneration Mark O'Driscoll (UK) Defective genome stability and impaired neurogenesis in congenital human disorders ...

Nitric oxide (NO) induces deamination of guanine, yielding xanthine and oxanine (Oxa). Furthermore, Oxa reacts with polyamines and DNA binding proteins to form cross-link adducts. Thus, it is of interest how these lesions are processed by DNA repair enzymes in view of the genotoxic mechanism of NO. In the present study, we have examined the repair capacity for Oxa and Oxa-spermine cross-link ad...

The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link between microvascular damage and fibrosis by transdifferentiating into myofibroblasts. We used a combination of immunohistochemistry and double immunofluorescence labelling of frozen skin biopsi...

One mechanism proposed as a link between exposure to ionizing radiation and detrimental effects on organisms is oxidative damage. To test this hypothesis, we surveyed the scientific literature on the effects of chronic low-dose ionizing radiation (LDIR) on antioxidant responses and oxidative damage. We found 40 publications and 212 effect sizes for antioxidant responses and 288 effect sizes for...

High O(2) consumption, modest antioxidant defenses and a lipid-rich constitution make the brain highly vulnerable to redox imbalances. Oxidative damage in the brain causes nervous system impairment. Recently, oxidative stress has also been implicated in depression, anxiety disorders and high anxiety levels. The findings which establish a link between oxidative stress and pathological anxiety ha...

The oilfield water in the Upper Sandstone Member of the Zubair reservoir (Barriemian-Hauterivian) at Rumaila North Oil Field was investigated for the interpretation of salinity and geochemical evolution of brine compositions. The interaction of the oilfield water with reservoir rock resulted in a brine water derived from the marine water origin of partial mixing with meteoric water similar to t...

as wireless networks with high data rate get widely deployed, improving the performance of tcp over these networks plays vital role. wireless link losses have dramatic adverse impact on tcp performance due to the difficulty in distinguishing the congestion losses from wireless link losses. we first, studied the various existing bandwidth estimation algorithms over the wireless networks. in this...

Background: The link prediction issue is one of the most widely used problems in complex network analysis. Link prediction requires knowing the background of previous link connections and combining them with available information. The link prediction local approaches with node structure objectives are fast in case of speed but are not accurate enough. On the other hand, the global link predicti...

In this study I will analyze the concept of damage as it is used in tort law. To do this, address three questions: first, there a single or multiple concepts harm? Second, what explanatory power comparative versus non-comparative criteria for determining constitutes Third, how are harm, interest and well-being linked? propose, first all, to these questions on basis certain debates held moral po...