Lipid nanoparticles of the cancer drug Chlorambucil (CLB) were prepared by ultrasonication, using stearic acid as the core lipid. Four types of lipid nanoparticle formulations were studied: (i) stearic acid solid lipid nanoparticles (SLN); (ii) sterically stabilized SLN with pegylated phospholipids as stabilizer; (iii) nanostructured lipid complexes with oleic acid as adjunct lipid; (iv) lipid ...

Abstract The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest significant entrants in development of drug delivery systems owing to their myriad advantages. NLCs second-generation SLNs having unstructured matrix, have high loading, provide long-term stability comparison other syst...

Ionizable Lipid Nanoparticles nanoparticle (LNP) systems are currently the leading nonviral delivery for enabling clinical potential of mRNA drugs. lipid is critical component nanoparticles. In article 2202590 by Gengshen Song, Jing Yang, Shengqi Wang, and co-workers, a novel ionizable YK009 designed developed LNP formulation. The YK009-LNP shows high efficacy good safety. An vaccine against SA...