Abstract Background Cancer of the breast is known to be among top spreading diseases on globe. Triple-negative cancer painstaking most destructive type mammary tumor because it spreads faster other parts body, with high chances early relapse and mortality. This research would aim at utilizing computational methods like quantitative structure–activity relationship (QSAR), performing molecular do...

Abstract Background 2,3-Dihydrobenzofurans (DHB) have proposed as advantages structures, and used chemical entresol to design small compound libraries. The present study illustrates explore 2,3-dihydrobenzofurans(DHB) in comparison selected some derivatives drugs by using molecular docking dynamics, well ADMET studies. online database “Molinspiration server” was detect the physicochemical pharm...

Mosquitoes are the primary vector for West Nile virus, a flavivirus. The virus’s ability to infiltrate and establish itself in increasing numbers of nations has made it persistent threat public health worldwide. Despite widespread occurrence this potentially fatal disease, no effective treatment options currently on market. As result, there is an immediate need research development novel pharma...

Melanoma affects more than a million people in the United States. Regardless of skin tone, anybody may get cancer. Poor bioavailability, adverse side effects, and drug resistance have hampered current state for treating cutaneous melanoma other malignancies. Medicinal chemists want to explore different possible novel drugs increase availability, diversity-oriented synthesis (DOS) strategy aimed...

BACKGROUND: Pain is a common symptom that managed in both outpatients and inpatients. There are many side effects associated with opioids such as respiratory depression, constipation, hyperalgesia, tolerance. Non- steroidal anti-inflammatory drugs cause gastrointestinal tract (GIT) irritation may be risk factor for developing peptic ulcer disease...

Abstract Background This study was designed to develop a reliable method for estimation of Ivacaftor and Tezacaftor in pure its pharmaceutical dosage form by RP-HPLC human plasma. Molecular docking studies were carried out the results visualized using PyMol Discovery studio visualizer (Discovery ver. 2.5). The pharmacokinetic properties such as Swiss ADME pKCSM metabolites M1, M6 M2 predicted. ...

Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bio-transformed by cytochrome P450 (CYP) enzymes, inhibition of CYP activity has long been associated with potentially adverse health effects. In an ...

The goal of this chapter is to explain some of the core concepts of Dynamic Field Theory (DFT) and how this theory provides a formal framework for thinking about embodied cognitive dynamics. The DFT is now 15 years old. In 1993, Gregor Schöner and his colleagues published a proceedings paper presenting a theory of how eye movements are planned, including their neural bases (Kopecz, Engels, & Sc...

12:645–652. 18. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, Kalantzi M, Herbots L, Sinnaeve P, Dens J, Maertens J, Rademakers F, Dymarkowski S, Gheysens O, Van Cleemput J, Bormans G, Nuyts J, Belmans A, Mortelmans L, Boogaerts M, Van de Werf F. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, ran...

Radiative properties of spherical heterogeneous particles consisting of threedimensionally ordered macroporous (3DOM) cerium dioxide (ceria) are numerically predicted in the spectral range 0.3–10μm. The particles are 1μm in diameter, with interconnected pores of diameter 330 nm and a face-centered cubic lattice arrangement. Predictions are obtained by solving macroscopic Maxwell’s equations usi...