An abnormal triglyceride-rich lipoprotein has been isolated from some patients with chronic renal failure or severe hypertriglyceridemia. The abnormal lipoprotein was characterized by an increased content of apolipoprotein (apo) C-III-2 (57.5% of total apo C-III peptides compared with 35.5% for controls, P less than 0.001) as characterized by isoelectric focusing and scanning densitometry. As d...

Lipoprotein lipase activity (LLA) was measured in the adipose tissue of six healthy subjects and five members of a family in whom the trait for familial exogenous hypertriglyceridemia was segregating. The lipase activity measured was characteristic of lipoprotein lipase: increased by feeding, dependent on the presence of serum, and inhibited by sodium chloride and protamine sulfate. When compar...

TRIGLYCERIDE, phospholipid, and cholesterol absorbed from the intestines are transported in the blood stream in the form of chylomicrons and very low density lipoproteins (VLDL)." There is considerable evidence that triglyceride of chylomicrons and VLDL is hydrolyzed during uptake from blood and that this process is catalyzed by lipoprotein l ipase. * Lipoprotein lipase activity is found in tis...

Twenty six preterm infants were studied at the age of 2, 7, and 26 days. The activities of lipoprotein and hepatic lipase in plasma taken 15 minutes after a heparin bolus of 100 IU/kg had been given and the concentrations of carnitine in serum and urine were measured. The mean gestational age was 31 weeks (range 26-35 weeks) and birth weight 1580 g (range 840-2280 g). Thirteen infants weighed u...

Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue. These differences included response to inhibitors and to high density lipoprotein in the incubation media. Heparin-released triglyceride lipase from liver, when compar...

Lipoprotein lipase, or lipemia clearing factor lipase (which is more accurate terminology [l]) , is a heparin-activated enzyme which has been found in rat, beef, and pig heart (2). The adipose tissues of rats, rabbits, and especially chickens contain greater quantities of the enzyme (3). This latter observation led to the suggestion that the major site of lipoprotein lipase activity was in the ...