A new study shows that phospho-dependent expulsion of type-1-phosphatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of Cyclin B-Cdk1 at the G2/M transition.

By parameterizing all reduced order models matching some of the first characteristic parameters (moments or Markov parameters or both) of the original system, the poles of the reduced system are prescribed as a key to find a stable reduced order system. Two procedures based on Lanczos and Arnoldi algorithms are proposed to approximate the dominant poles of the original system and to choose them...