Several heart muscle diseases can cause failure, the etiological diagnosis of which may serve basis targeted, tailored, effective personalized therapy. Such a disease is transthyretin amyloidosis (ATTR) an infiltrative disorder affecting most frequently and peripheral nerves, due to accumulation protein. Deposition mutant transthyretin, mutations in TTR gene encoding for occurs familial form (h...

Avian amyloid A (AA) amyloidosis is commonly observed in adult birds with chronic inflammation, such as that caused by bacterial infection. We previously described vaccine-associated AA amyloidosis in juvenile chickens. In this study, the prevalence of amyloid deposition was measured in mature healthy chickens that survived a previous outbreak of avian AA amyloidosis while they were juveniles. ...

Extracellular deposits of insoluble proteinaceous material giving a starchlike reaction when treated with iodine and sulphuric acid and accumulating in tissue was for the first time described by Rokitansky in 1842 [1]. It was not until 1851 that Virchow applied the term “amyloidosis” to describe this deposition [2]. An amorphous substance called amyloid (insoluble fibril-forming protein) is dep...

Cardiac amyloidosis is a rare and complex pathology resulting in infiltrative restrictive cardiomyopathy and there are only very few clinical pathways through which the diseased amyloidotic heart may be a subject of cardiosurgical intervention. Cardiac surgery may rarely be warranted in very selected cases, and, on the other hand, may be performed mistakenly in misdiagnosed patients with cardia...

The risk of a posttransplant recurrence of secondary glomerulonephritis (GN) is quite variable. Histologic recurrence is frequent in lupus nephritis, but the lesions are rarely severe and usually do not impair the long-term graft outcome. Patients with Henoch-Schonlein nephritis have graft survival similar to that of other renal diseases, although recurrent Henoch-Schonlein nephritis with exten...

Heart failure is a common clinical syndrome caused by a variety of cardiac diseases. We report a rare case of familial transthyretin amyloidosis cardiomyopathy to heighten the awareness of this rare but lethal cause of heart failure, as therapeutic interventions such as liver or heart transplant could be curative in selected patients.

The definitive diagnosis of amyloidosis is made histologically with Congo red stain. Noninvasive imaging techniques for amyloidosis are beneficial for early and definite diagnosis of amyloid deposition in the body. (99m)Tc-aprotinin has the benefit of detecting amyloid deposits mainly in the heart, but it can also detect a wide range of lesions in other locations. The usefulness and limitations...