Cirrhosis is an increasing cause of morbidity and mortality in more developed countries, being the 14th most common cause of death worldwide but fourth in central Europe. Increasingly, cirrhosis has been seen to be not a single disease entity, but one that can be subclassified into distinct clinical prognostic stages, with 1-year mortality ranging from 1% to 57% depending on the stage. We revie...

Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide, particularly in South and South East Asia. Unfortunately due to lack of appropriate facilities and awareness only limited information is available about its early diagnosis. Aim of the present study was to determine the efficacy of p53 by immunohistochemistry and Argyrophilicnucleolar organizer regions (AgNORs) in d...

Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15-30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many...

Cirrhosis is the end result of chronic liver damage, associated with altered serum biomarkers and lipid profile. However, only few studies regarding serum biomarkers and plasma lipid profile in non-alcoholic liver cirrhosis subjects have been undertaken in Pakistan. This study aimed to evaluate the degree of alterations of tumor markers and lipid profile in liver cirrhosis patients and in norma...

The goal of this study was to investigate the utility of H magnetic resonance spectroscopy (H-MRS) to quantify the differences in liver metabolites. Magnetic resonance spectroscopy was used as a means of predicting the probability of developing hepatocellular carcinoma (HCC) in patients with liver cirrhosis secondary to chronic hepatitis B.This study included 20 healthy volunteers, 20 patients ...

conclusion due to the significant improvement in the treatment of early stage of hcc compared to the previous decade, we suggest a fast, non-invasive, more accurate, but more expensive method (haste, op/ip t1w sequences mri combined with dwi) rather than us for the screening of hcc in liver cirrhosis. results combination of limited sequences mri and dwi had the highest accuracy (94.79%) followe...

conclusions serum stnfr-iiα could be used as a potential serum marker in diagnosing hcc among patients with hcv infection. results the serum level of stnfr-iiα was significantly higher in patients with hcc in comparison to the other groups. a positive correlation was found between the serum levels of stnfr-iiα and ast and alt in patients of group-ii. diagnosis of hcc among patients with hcv inf...

conclusions fib-4 confirmed the best value for diagnosis of significant fibrosis. apri had a sub-optimal diagnosis accuracy for significant fibrosis. lsm showed the most balance diagnosis value for cirrhosis with the highest sensitivity and moderate specificity. patients and methods a total of 544 patients with chb were assessed for fibrosis stage by four noninvasive tests containing liver stif...

background : data mining has an interdisciplinary field including various scientific disciplines such as: database systems, statistics, machine learning, artificial intelligence and the others. in the field of medical, data mining algorithms can help physicians to diagnose diseases and chose the best type of treatment. hepatocellular carcinoma has the most common type of liver cancer. given the...