Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver require active combined therapy. For unresectable neuroendocrine metastases, transplantation has become potential definitive treatment due slow growth clinical course metastatic process. We conducted review relevant literature, criteria for including excl...

nloaded pose: To clarify and compare the antitumor effects and specific biodistribution of NK012, an –incorporating polymeric micelle, in mice bearing multiple liver metastases of human colon cancer cells with irinotecan hydrochloride (CPT-11). erimental Design: The maximum tolerable dose of NK012 (30 mg/kg) or CPT-11 (66.7 mg/kg) v. administered three times every 4 days to mice bearing metasta...

To improve the quality of life and outcomes for patients with colorectal liver metastases, we would like to emphasize some points. First, a colorectal multidisciplinary teams (MDT) should also include a specialized hepatobiliary MDT that has the expertise and the facilities to provide surgery for patients with liver metastases. The cases of patients being considered for treatment of hepatic met...

Patients with hepatic metastases from colorectal cancer have a poor prognosis, with a median survival of less than 12 months. Although chemotherapy may have a beneficial effect on the natural history of unresected liver metastases, 5-year survival is difficult to achieve by chemotherapy alone. Hepatic resection can achieve prolonged survival with an acceptable mortality risk in selected patient...

The diagnosis and management of CRLM is complex and requires a multidisciplinary team approach for optimal outcomes. Over the past several decades, the 5-year survival following resection of CRLM has increased and the criteria for resection have broadened substantially. Even patients with multiple, bilateral CRLM, previously thought unresectable, may now be candidates for resection. Two-stage h...

BACKGROUND The liver is the most frequent site of metastatic disease, and metastatic disease to the liver is far more common than primary liver carcinoma in the United States. Pathologic evaluation of biopsy samples is key to establishing a correct diagnosis for patient management. Morphologic and immunoperoxidase studies, which are the standard for pathologic practice, accurately classify most...

Downloa ors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and vasculature differs significantly between the lung and liver. Vascular endothelial growth factor (VEGF GF-A) promotion of tumor angiogenesis is thought to be mediated primarily by VEGF receptor-2 R-2). In this study, VEGFR-2 antibody (DC101) inhibited growth of RenCa renal cell carcino...

OBJECTIVE To assess the clinical characteristics and outcome of patients with liver metastases in prostate carcinoma. PATIENTS AND METHODS From January 1995 to December 2005, 345 patients with metastatic prostate cancer were prospectively recorded in the database of the Montpellier Cancer Centre, France. The clinical characteristics and outcome of 28 patients who developed liver metastases du...

Liver transplantation is an option that improves quality of life and prolongs life expectancy in patients with different types of liver disease. Liver transplantation is controversial for colorectal metastases and is not recommended in clinical practice guidelines. In this case report, we present, to our knowledge, the first liver transplantation for colorectal metastases conducted in Colombia,...

Few epidemiologic studies describe longitudinal liver chemistry (LC) elevations in cancer patients. A population-based retrospective cohort was identified from 31 Phase 2-3 oncology trials (excluding targeted therapies) conducted from 1985 to 2005 to evaluate background rates of LC elevations in patients (n = 3998) with or without liver metastases. Patients with baseline liver metastases (29% o...