background and objective: obesity in childhood increases the risk of fatty liver disease. with respect to the increased prevalence of obesity in iran and the world, this study aimed to investigate the relationship between fatty liver and obesity in 6 -18 year-old children. methods: in this case-control study, 25 overweight children and 24 obese children, who had inclusion criteria, were selecte...

Recent advances in sequencing technology have allowed us to profile genome-wide mutations of various cancer types, revealing huge heterogeneity of cancer genome variations. However, its heterogeneous landscape of somatic mutations according to liver cancer progression is not fully understood. Here, we profiled the mutations and gene expressions of early and advanced hepatocellular carcinoma (HC...

Cancer genome sequencing has identified numerous somatic mutations whose biologic relevance is uncertain. In this study, we used genome-editing tools to create and analyze targeted somatic mutations in murine models of liver cancer. Transcription activator-like effector nucleases (TALEN) were designed against b-catenin (Ctnnb1) and adenomatous polyposis coli (Apc), two commonly mutated genes in...

Nowadays, studies of metabolic pathways and processes in living organisms cannot be easily done at the cellular level. That is why the development of a new analytical methods and approaches is needed, to allow detection of different biologically important species at very low concentrations levels and sample volumes, especially in individual cells. In the present work, we suggested a sensor to d...

AIMS/INTRODUCTION To examine the association between liver histological features and organ-specific insulin resistance indices calculated from 75-g oral glucose tolerance test data in patients with non-alcoholic fatty liver disease. MATERIALS AND METHODS Liver biopsy specimens were obtained from 72 patients with non-alcoholic fatty liver disease, and were scored for steatosis, grade and stage...

The study of clinical and anamnestic paraclinical characteristics, highlighting their dominant features in patients with DP existing thyroid diseases occupies an important place modern neuroendocrinology requires more focused attention clinicians.
 objective: to determine the leading laboratory-instrumental parameters pathology, analyze mutual influence neuroendocrine pathology on patient’...

AIM To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, C...

Background: Non-alcoholic fatty liver disease (NAFLD) is increasingly a common disease which is created by the accumulation of fat in the liver. About 20% of adults and 5% of children suffer from this disease. In some studies, half of obese children had fatty liver disease and approximately 90% of the patients with fatty liver were obese. The aim of this study was to evaluate fatty liver diseas...