tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. to date, there is no information on the pharmacokinetics of tacrolimus in iranian liver transplant recipients. this study was designed to determine pharmacokinetic properties of orally administe...

The main goal of 2-stage liver transplant is to provide time to obtain a new liver source. We describe our experience of 3 patients with 3 different clinical conditions. A 57-year-old man was retransplanted successfully with this technique due to hepatic artery thrombosis. However, a 38-year-old woman with fulminant toxic hepatitis and a 5-year-old-boy with abdominal trauma had poor outcome. Th...

The shortage of organs forces coordinators to seek new forms of generating organs for transplantation of the increasing numbers of patients on waiting lists. A recent technique called sequential transplant or domino liver transplant (DLT) allows the transplantation of a patient with chronic liver disease by implantation of a full-size liver derived from a patient with familial amyloidosis polyn...

PurposeUnlike Fontan-associated liver disease, the impact of heart transplant (HT) on Fontan associated kidney disease has not been well described. In this single center study, we sought to characterize natural history chronic in a small cohort patients from listing follow up after HT.MethodsWe conducted retrospective review pediatric at our institution with prior palliation that underwent HT b...

P REVIOUS studies in liver transplant patients have demonstrated that liver allografts matched for HLA. especially HLA-DR, have lower survival rates, raising the concept that HLA plays a dualistic role in liver transplan-tation. HLA matching will reduce rejection but may augment other major histocompatibility complex (MHC) restricted cellular immune mechanisms of liver allograft injury. 1.2 The...

The present study was conducted in Internal Medicine Department of Kasr Al-Ainy Hospital and Kasr Al-Ainy Liver Transplant Unit, Cairo University between September 2014 and March 2015. This descriptive study was conducted on 48 patients divided into 2 groups: 1Group 1 (liver cirrhosis patients who are suffering from infection, 40 patients). 2Group 2 (post-liver transplant patients, 8 patients).

Liver transplant activity started in Spain in 1984 and has reached 16,132 interventions at 31st December 2008, with a mean activity of more than 1000 transplants during the last years. There are 25 transplant teams (1/1.85 million inhabitants), two of them paediatric. The maximum activity has been recorded at the Hospital La Fe (Valencia) with 1,557 transplants (more than 100 annually). The maj...

BACKGROUND The strongest predictor of tumor relapse after liver transplantation for hepatocellular carcinoma (HCC) is vascular invasion, appreciated only on explant analysis. High serum level of vascular endothelial growth factor (VEGF) is associated with worse outcomes after resection or locoregional therapies but its role in liver transplantation remains undefined. OBJECTIVE We report the f...

Liver transplant can be challenging in cirrhotic patients with diabetes mellitus. In chronic liver disease, the glucose metabolism is altered; uncontrolled diabetes negatively influences the outcome of liver transplantation and poses difficulty in the management of immediate post transplantation period. Simultaneous liver-pancreas transplantation is an option to prevent early complications due ...

Ivan Bradford is a fifty-five year old, white male in need of a liver transplant. Ivan has been an alcoholic since he was thirty-two years old, and has developed an irreversible advanced liver disease, cirrhosis. In essence, the disease is the end result in scarring of the liver due to prolonged alcohol abuse. This scarring prevents the liver from performing many of its vital functions. Without...