PURPOSE Intravenous lipid emulsions have been used to treat the systemic toxicity of local anesthetics. The goal of this in vitro study was to examine the effects of lipid emulsions on the norepinephrine-mediated reversal of vasodilation induced by high doses of levobupivacaine, ropivacaine, and mepivacaine in isolated endothelium-denuded rat aorta, and to determine whether such effects are ass...

Tumescent anesthesia is a local anesthetic technique that consists of the infiltration of a large volume of solution with a low concentration of the local anesthetic agent and epinephrine. Its main advantages are that it achieves adequate anesthesia and a significant reduction in intraoperative and postoperative bleeding, leading to greater ease of surgery with the added benefit that it facilit...

Background: Lidocaine, the first commercialized amide local anesthetic, is still the most widely used anesthetic in some countries. It is considered as a reference for new local anesthetics. Bupivacaine, an amide-type local anesthetic, provides prolonged analgesia and is indicated when post-operative pain is anticipated. Aim: To compare efficacy of lidocaine with and without bupivacaine as a de...

PURPOSE The purpose of this survey is to evaluate current usage of local and topical anesthesia by Pediatric Dentist to evaluate the current practices. METHODS Surveys were sent to 3051 pediatric dentists asking about types of anesthetics, considerations in determining local anesthetic dosage, time used to inject a cartridge and shortcomings of topical preparations. Data were computed for per...

OBJECTIVE To analyze the effect of infiltration of local anesthetics on postoperative pain relief. DESIGN Prospective randomized double-blind trial. Setting. University Teaching Hospital in Barbados, West Indies. PATIENTS Patients undergoing total abdominal hysterectomy. Interventions. Patients were randomly allocated into one of four groups according to the wound infiltration: 1) preoperat...