نتایج جستجو برای: local hyperthermia
تعداد نتایج: 540350 فیلتر نتایج به سال:
Local chest wall progression of chemotherapy/radiation-resistant breast cancer can result in substantial morbidity. In this retrospective review of 39 patients in this difficult clinical setting treated at Cancer Treatment Centers of America (Eastern Regional Medical Center), approximately one-half of the population experienced meaningful short-term palliation and improvement in quality of life...
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival. Therefore, systemic chemotherapy has been integrated either after (adjuvant) or before (neoadjuvant) optimal local treatment by surgery and radiotherapy in HR-STS. The combination with regional hyperthermia as a new treatment strategy s...
Introduction Hyperthermia therapy is commonly used for tumor treatment that already has been widely investigated. The principle of hyperthermia therapy employs the clear difference in heat sensitivity of normal cells and tumor cells at 42°C to 43°C and above. This difference is used for selective killing of only the tumor cells. Recently, hyperthermia therapy combined with magnetic resonance im...
To test the hypothesis that bradykinin effects cutaneous active vasodilation during hyperthermia, we examined whether the increase in skin blood flow (SkBF) during heat stress was affected by blockade of bradykinin B(2) receptors with the receptor antagonist HOE-140. Two adjacent sites on the forearm were instrumented with intradermal microdialysis probes for local delivery of drugs in eight he...
BACKGROUND & AIMS This study was designed to evaluate the efficacy and safety of combination transarterial chemoembolization (TACE) followed by radiotherapy (RT) and hyperthermia (CERT) in hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). METHODS This single-institution, single-arm, prospective phase II study was performed from October 2013 to February 2016. The objecti...
A clinical trial was performed to investigate the efficacy of hyperthermia in combination with chemotherapy for gynecological malignancies. Sixty-nine patients with vaginal or vulvar malignancies (9 primary vulvar, 3 recurrent vulvar, 11 primary vaginal, 4 primary cervical, 40 recurrent cervical, and 2 recurrent ovarian carcinomas) were treated by thermochemotherapy (42 cases) or chemotherapy a...
Objective: Febrile seizures are the most common seizure disorder in childhood, and occur in 2-5% of children. While simple febrile seizures are frequently described as inoffensive disorder there are evidence suggesting the association between simple febrile seizures and hippocampal abnormalities in adulthood. This study was designed to evaluate the protein levels of Bcl-2 and Bax in the rat neo...
Due to importance of combination therapies in cancer treatment, this study was performed to find the effects of hyperthermia and neutron irradiation and heir combination on the human lymphocytes. Blood samples were treated separately with 41.5 °C for 30 and 60 minutes, 43 °C for 15 and 30 minutes, as well as 10 cGy neutron irradiation. They also treated with hyperthermia followed by irradiation...
BACKGROUND We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). In this study, the in vivo effect of hyperthermia mediated by MCLs was examined using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model. METHOD MCLs were injected in...
The effect of withaferin A, a plant withanolide, alone or in combination with acute and fractionated radiotherapy and/or hyperthermia, was tested on two mouse tumors, B16F1 melanoma and fibrosarcoma, grown in C57BL and Swiss albino mice, respectively. Tumors were exposed locally to 30 or 50 Gy gamma radiation as acute dose, or 5 fractions of 10 Gy. Withaferin A, 40 mg/kg, was injected intraperi...
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