Pain relief following total knee arthroplasty (TKA) is challenging because early mobilization and rehabilitation are essential for a successful outcome. Postoperative pain can limit recovery, leading to reduced mobility and prolonged hospitalization. There are potential benefits of infiltrating high volumes of local anesthetics around the soft tissues of replaced hip and knee joints. The risk o...

Pain, which is often inadequately treated, accompanies the more than 23 million surgical procedures performed each year and may persist long after tissue heals. Preemptive analgesia, an evolving clinical concept, involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could ...

Post-tonsillectomy pain is a common concern. This study aimed to assess the effectiveness of peritonsillar infiltration tramadol during tonsillectomy in terms analgesia requirement, scores and time commencement liquid diet, as there heterogeneity randomized controlled trials conducted.

BACKGROUND The addition of small amounts of dexamethasone to extended-release formulations of bupivacaine in microcapsules has been found to prolong local analgesia in experimental studies, but no clinical data are available. METHODS In a double-blinded study, 12 healthy male volunteers were randomized to receive simultaneous subcutaneous injections of bupivacaine microcapsules with dexametha...

1 Dahlmann AH, Appaswamy S, Headon MP. Orbital cellulitis following subTenon’s anaesthesia. Eye 2002; 16: 200–1. 2 Stevens JD. A new local anaesthesia technique for cataract extraction by one quadrant sub-Tenon’s infiltration. British Journal of Ophthalmology 1992; 76: 670–4. 3 Guise PA. Single quadrant sub-Tenon’s block. Evaluation of a new local anaesthetic technique for eye surgery. Anaesthe...

BACKGROUND: We report a case of a patient with apparent resistance to local anesthetics. While similar cases of failure of regional anesthetics are often attributed to technical failure, the overall clinical presentation and history of this patient suggests a true resistance to local anesthetics. CASE PRESENTATION: This patient presented for elective cesarean section and the decision for region...

BACKGROUND Randomized trials evaluating efficacy of local infiltration analgesia (LIA) have been published but many of these lack standardized analgesics. There is a paucity of reports on the effects of LIA on functional capability and quality of life. METHODS 56 patients undergoing unilateral total knee arthroplasty (TKA) were randomized into 2 groups in this placebo-controlled study with 12...