Summary : Skin melanoma is one of the deadliest among human skin tumors, and surgery remains first main method in its combined treatment. Despite seemingly radical nature surgical interventions patients with primary melanoma, frequency locoregional recurrence metastasis high. The question impact treatment on evolution microenvironment unclear. Aim to investigate dynamics polarization tumor-asso...

BACKGROUND Malignant salivary gland tumors are rare tumors of the head and neck region. The treatment of these tumors has generally consisted of surgical extirpation, with postoperative radiotherapy improving locoregional control and survival in patients with high risk tumors. Neutron radiotherapy has been found to be more efficacious than conventional radiotherapy in the setting of inoperable ...

Background The purpose of this study is to assess the role of locoregional radiotherapy (RT) when used in combination with systemic chemotherapy, for patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC), in a non-endemic region of northern China. Methods In total, 611 patients with NPCs were newly diagnosed between June 2011 and June 2016 following visits to our hospital; o...

BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that is strongly associated with oxidative damage and oxidative stress. Tobacco and alcohol - sources of massive quantities of reactive oxygen species (ROS) - have been clearly identified as etiologic factors that contribute to these malignancies. Considering the role of glutathione (GSH) in ROS detoxification, we hypo...

INTRODUCTION Age is an important prognostic factor in differentiated thyroid cancer (DTC). Our aim was to evaluate differences in clinicopathological features and treatment outcomes among children and adult patients with DTC. MATERIALS AND METHODS We studied 27 children (below 18 years) with DTC treated during the period 2000-2012 and were compared with (a) 78 adults aged 19-25 years and (b) ...

Aim: Initial staging in breast cancer is considered as locoregional and systemic disease. Distant metastases is rarely expected in early stage breast cancer patients. Although, we observed that, stage is not as clinically expected after staging with FDG PET-CT both in early and advanced stage breast cancer. Our main objective was to test the hypothesis by comparing the distant metastases rate o...

PURPOSE To evaluate the therapeutic results and histopathological effects of treatment with thermochemoradiation therapy using superselective intra-arterial infusion via the superficial temporal and occipital arteries for N3 cervical lymph node metastases of advanced oral cancer. METHODS AND MATERIALS Between April 2005 and September 2010, 9 patients with N3 cervical lymph node metastases of ...