#### Notable in Neurology This Week issue features an article that validates the use of plasma Aβ42/Aβ40 to detect amyloid plaques patients with Alzheimer disease; another investigates how age at which children have a stroke affects long-term cognitive outcome. A featured Research Article examines risk cerebral venous sinus thrombosis after SARS-CoV-2 vaccination. ### Association Cognitive Impa...

We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. Dexmedetomidine decreased both noradrenaline release and cell firing rate in a concentration-dependent fashion, with an EC50 of 3.97 (SEM 0.97) x 10(-9) mol litre-1 for noradrenaline release and 0.92 (...

Many psychophysiologists have noted the striking similarities between the antecedent conditions for the P3 component of the event-related potential and the orienting response: both are typically elicited by salient, unexpected, novel, task-relevant, and other motivationally significant stimuli. Although the close coupling of the P3 and orienting response has been well documented, the neural bas...