Roads in the Netherlands are often heavily congested. Real-time travel time information can be a valuable instrument to reduce the impact of increasing traffic demand on travel time with advantages for traffic participants as well as for the traffic network managers. For urban roads travel time estimation is a more complex problem than for freeways. In order to provide online, real-time and acc...

Segmental Minimum Bayes Risk (SMBR) Decoding is an approach whereby we use a decoding criterion that is closely matched to the evaluation criterion (Word Error Rate) for speech recognition. This involves the refinement of the search space into manageable confusion sets (ie, smaller sets of confusable words). We propose using Support Vector Machines (SVMs) as a discriminative model in the refine...

Background and aim Continuation of healthy nutritional behaviors is one of the important factors in effectiveness of educational intervention programs. The aim of this research is to compare the Health Belief Model and the Ecological-social model in reducing consumption of rice contaminated with toxic metals after completion of environmental intervention and continuation of consumption of healt...

BACKGROUND Computerized decision support systems (DSS) have mainly focused on improving clinicians' diagnostic accuracy in unusual and challenging cases. However, since diagnostic omission errors may predominantly result from incomplete workup in routine clinical practice, the provision of appropriate patient- and context-specific reminders may result in greater impact on patient safety. In thi...

It is common that in all academic systems the students must make decisions about the future by choosing among different alternatives that include professional profiles or modalities, elective subjects or optional, etc. These decisions can have a very important influence in the academic journey of the students because sometimes a wrong decision can lead to academic failure or its correction impl...

Formation of the early vertebrate embryo depends on a Brachyury/Wnt autoregulatory loop within the posterior mesodermal progenitors. We show that exogenous retinoic acid (RA), which dramatically truncates the embryo, represses expression of the zebrafish brachyury ortholog no tail (ntl), causing a failure to sustain the loop. We found that Ntl functions normally to protect the autoregulatory lo...

The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally over a subset of transcription termination regions. There it mediates the recruitment of a specif...

Gene silencing by RNA interference (RNAi) can be achieved by the ectopic expression of tailored short hairpin RNAs (shRNAs) which after export to the cytoplasm are processed by Dicer and incorporated into the RNA induced silencing complex (RISC). Design rules for shRNAs have been the focus of several studies, but only a few reports have turned the attention to the sequence of the loop-region. I...

Site layout planning can affect productivity and is crucial to project success. However, as construction is heterogeneous in the nature of its organizations, project designs, time constraints, environmental effects, etc., site layout planning for each project becomes unique. Affected by many uncertainties ~variables! and variations, site layout planning is a typical multiobjective problem. To f...

A prerequisite to understand neuronal function and characteristic is to classify neuron correctly. The existing classification techniques are usually based on structural characteristic and employ principal component analysis to reduce feature dimension. In this work, we dedicate to classify neurons based on neuronal morphology. A new feature selection method named binary matrix shuffling filter...