Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known phytochemicals used at bioavailable levels could induce 100% killing of breast...

The metabolism and disposition of [(14)C]apixaban, an orally bioavailable, highly selective, and direct acting/reversible factor Xa inhibitor, was investigated in 10 healthy male subjects without (group 1, n=6) and with bile collection (group 2, n=4) after a single 20-mg oral dose. Urine, blood, and feces samples were collected from all subjects. Bile samples were also collected for 3 to 8 h af...

the study aimed to come up with a list of specific macroalgae species, which could be used to biomonitor specific metal elements in the coastal waters of east africa. water extraction, edta, aqua regia extraction and optimized bcr 3-step sequential extracts were used to mimic bioavailable metals under various environmental conditions. the results indicated that ulva lactuca could be used as a b...

BACKGROUND Symptoms of late-onset hypogonadism (LOH) and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in relation to the data from the same men 5 years earlier. METHODS In 2008, 282 men, aged 60-82 years, answered a questionnaire regarding demographic data, medical history, different symptoms of LOH and the 10 questions from the 'Androgen Decline in Aging...

Serum concentrations of neuroactive androgens decline in older men and, in some studies, low testosterone is associated with decreased cognitive function and incidence of depression. Existing studies evaluating the effect of testosterone administration on cognition in older men have been largely inconclusive, with some studies reporting minor to moderate cognitive benefit, while others indicate...

Azithromycin is a semisynthetic macrolide antibiotic representing the first of a subclass of macrolides classified as azalides. A relative newcomer to veterinary medicine azithromycin was first described in the late 1980s and differs from erythromycin by the insertion of a methyl-substituted nitrogen on the lactone ring at position 9a.1 This addition creates a 15-membered macrolide. The alterat...

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Rivers are critical links in the carbon and nitrogen cycle in aquatic, terrestrial, and atmospheric environments. Here riverine carbon and nitrogen exports in nine large rivers on the Tibetan Plateau - the "Water Tower of Asia" - were investigated in the monsoon season from 2013 to 2015. Compared with the world average, concentrations of dissolved inorganic carbon (DIC, 30.7mg/L) were high in r...