We studied the gene expression profile during cardiac hypertrophy induced by angiotensin (ANG) II in wild-type mice and the influence of LOX-1 deletion on the gene expression profile. Wild-type and LOX-1 knockout mice were given saline or ANG II infusion for 4 wk. The saline-treated LOX-1 knockout mice showed upregulation of several genes including Ddx3y and Eif2s3y. ANG II infusion enhanced ex...

Introduction LOX-1, the lectin-like oxidized low-density lipoprotein (LDL) receptor, is the major receptor for oxidized LDL (OxLDL). This enzyme plays a critical role in endothelial dysfunction and injury, leading to initiation and progression of atherosclerosis. LOX-1 belongs to the Ctype lectin family, and human LOX-1 constitutes of cytoplasmic domain, transmembrane domain (TM), NECK domain a...

Cross talk between oxidized LDL (ox-LDL) and angiotensin II (Ang II) may be relevant in atherosclerosis. In this study, we examined the presence of a specific endothelial receptor for ox-LDL (LOX-1) and Ang II receptors in human coronary artery endothelial cells (HCAECs). In addition, we studied the effect of Ang II on LOX-1 gene and protein expression. LOX-1 was consistently identified in HCAE...

The identification of new biomarkers and targets for tailored therapy in human colorectal cancer (CRC) onset and progression is an interesting challenge. CRC tissue produces an excess of ox-LDL, suggesting a close correlation between lipid dysfunction and malignant transformation. Lectin-like oxidized LDL receptor-1 (LOX-1) is involved in several mechanisms closely linked to tumorigenesis. Here...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

Atherosclerosis is a chronic systemic inflammatory disease; the end-stage of which is plaque rupture. This depends on plaque composition and vulnerability rather than the severity of stenosis [1]. Vulnerable plaques are associated with an intense inflammatory response and a thin fibrous cap [2]. Remodeling and degradation of the extracellular matrix (ECM) and fibrous cap are maintained by the p...

Hugo: ALOX12 Other names: 12-LOX; 12S-type; 12(S)-lipoxygenase; EC 1.13.11.31; LOG12 Location: 17p13.1 Local order: According to NCBI Map Viewer, genes flanking ALOX15 in centromere to telomere direction on 17p13 are: GABARAP 17p13.1 GABA(A) receptorassociated protein, ASGR2 asialoglycoprotein receptor 2, ALOX12 17p13.1 arachidonate 12-lipoxygenase (Homo sapiens), ALOX12P2 17p13 arachidonate 12...

LOX-1 is a multifunctional membrane receptor that binds and internalizes oxidized LDL (oxLDL). We tested the hypothesis that blockade of LOX-1 with an anti-LOX-1 antibody limits nephropathy in male rats with diabetes and dyslipidemia (ZS rats; F(1) hybrid product of Zucker fatty diabetic rats and spontaneous hypertensive heart failure rats). Lean ZS rats were controls, while untreated obese ZS ...