Objectives: To determine the predictive risk factors for isolated locoregional recurrence (LRR) in breast cancer patients with postmastectomy adjuvant therapy. Patients and Methods: The impacts of patients’ characteristics, tumor stage, and surgery on LRR were evaluated in patients with breast cancer having postmastectomy adjuvant therapy, according to their risk factors using univariate analys...

LRR-kinases constitute the largest subfamily of receptor-like kinases in plants and regulate a wide variety of processes related to development and defense. Through a reiterative process of sequence analysis and re-annotation, we identified 309 LRR-kinase genes in the rice genome (Nipponbare). Among them, 127 genes in the Rice Annotation Project Database and 85 in Refseq of NCBI were amended (i...

We analyze and improve low rank representation (LRR), the state-of-the-art algorithm for subspace segmentation of data. We prove that for the noiseless case, the optimization model of LRR has a unique solution, which is the shape interaction matrix (SIM) of the data matrix. So in essence LRR is equivalent to factorization methods. We also prove that the minimum value of the optimization model o...

In innate immune sensing, the detection of pathogen-associated molecular patterns by recognition receptors typically involve leucine-rich repeats (LRRs). We provide a categorization of 375 human LRR-containing proteins, almost half of which lack other identifiable functional domains. We clustered human LRR proteins by first assigning LRRs to LRR classes and then grouping the proteins based on t...

We analyze and improve low rank representation (LRR), the state-of-the-art algorithm for subspace segmentation of data. We prove that for the noiseless case, the optimization model of LRR has a unique solution, which is the shape interaction matrix (SIM) of the data matrix. So in essence LRR is equivalent to factorization methods. We also prove that the minimum value of the optimization model o...

The NOD-like receptor NLRP1 (NLR family, pyrin domain containing 1) senses the presence of the bacterial cell wall component l-muramyl dipeptide (MDP) inside the cell. We determined the crystal structure of the LRR domain of human NLRP1 in the absence of MDP to a resolution of 1.65Å. The fold of the structure can be assigned to the ribonuclease inhibitor-like class of LRR proteins. We compared ...

Actin dynamics is fundamental for neurite development; monomer depolymerization from pointed ends is rate-limiting in actin treadmilling. Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1-Tmod3 are expressed in brain cells. We investigated the role of Tmod's C-terminal (LRR) domain in the formation of neurite-like processes by overexp...

The molecular mechanisms that regulate cell cycle progression in a developmental context are poorly understood. Here, we show that the leucine-rich repeat protein LRR-1 promotes cell cycle progression during C. elegans development, both in the germ line and in the early embryo. Our results indicate that LRR-1 acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (...

The link reversal routing (LRR) algorithm maintains loop free routes in mobile ad hoc wireless networks while incurring low overhead. In this paper we explore the problem of balancing the load of forwarding traffic in LRR algorithm. We make some important observations regarding the situations that lead to load unbalance in the LRR algorithm and formally define the load balancing problem. Based ...

Abstract Plant intracellular immune receptors known as NLR (Nucleotide-binding Leucine-rich repeat, NB-LRR) proteins confer resistance and cause cell death upon recognition of cognate effector from pathogens. NLRs contain a variable N-terminal domain: Toll/interleukin-1 receptor (TIR) domain or coiled-coil (CC) an RPW8 (Resistance to Powdery Mildew 8)-like CC (CC R ) domain. TIR-NLR, CC-NLR -NL...