OBJECTIVE Conventional survival estimates may be biased if loss to follow-up (LTF) is associated with the outcome of interest. Our goal was to assess whether the association between sexual risk behavior and HIV-1 acquisition changed after accounting for LTF with competing risks regression. METHODS HIV-1-seronegative women who enrolled in a Kenyan sex worker cohort from 1993-2007 were followed...

The purpose of this document is to summarize the talk I gave at the property testing workshop at ITCS in January 2010or more accurately, the talk I would have given, had I not been sick with the flu. In my absence, Rocco Servedio actually gave the talk. Here I will attempt to summarize what I would have said, or what Rocco might have said, or some combination of the two. The purpose of the talk...

UNLABELLED Although rats are a frequent model for studies of plasticity in respiratory motor control, the relative capacity of rat accessory respiratory muscles to express plasticity is not well known, particularly in unanesthetized animals. Here, we characterized external intercostal (T2, T4, T5, T6, T7, T8, T9 EIC) and abdominal muscle (external oblique and rectus abdominis) electromyogram (E...

The T5-like siphoviruses DT57C and DT571/2, isolated from horse feces, are very closely related to each other, and most of their structural proteins are also nearly identical to T5 phage. Their LTFs (L-shaped tail fibers), however, are composed of two proteins, LtfA and LtfB, instead of the single Ltf of bacteriophage T5. In silico and mutant analysis suggests a possible branched structure of D...

This study was designed to test the hypothesis that the medullary lateral tegmental field (LTF) is an important synaptic relay in the baroreceptor reflex pathway controlling sympathetic nerve discharge (SND) of urethan-anesthetized cats. We determined the effects of blockade of excitatory amino acid-mediated neurotransmission in the LTF on three indexes of baroreceptor reflex function: cardiac-...

BACKGROUND Lactoferrin, an innate immune protein with antiinflammatory properties, shows considerable antiatherosclerosis activity in animal studies. We investigated the relationship between circulating lactoferrin, lactoferrin gene (LTF, lactotransferrin) polymorphisms, dyslipidemia, and vascular reactivity in the context of glucose-tolerance status in men. METHODS We evaluated 2 nonsynonymo...

To evaluate knot security, loop and size of suture tape wire. The single load to failure (LTF) cyclic loading one arthroscopic (Samsung Medical Center [SMC]) hand-tied (surgeon’s knot) using two tapes (Broadband-[BB], Suture Tape-[ST]) No. 2 wires (MaxBraid-[MB], FiberWire-[FW]). A third (FiberTape-[FT]), not commonly tied arthroscopically, was included in the group. Ten samples for each suture...

STUDIES CARRIED OUT more than 50 years ago demonstrated that electrical stimulation of sites within a large part of the dorsolateral reticular formation in the medulla oblongata can produce large increases in arterial pressure (1, 21). These early studies led to the view that neurons controlling the sympathetic outflow to the heart and blood vessels are distributed diffusely throughout this pon...

Background Alzheimer’s disease (AD) affects millions of people with no effective treatments making it vital to identify potential therapeutic targets. Genome-wide association studies (GWAS) have consistently identified AD susceptibility loci or ‘hits’. Few these are differentially expressed in brain transcriptomic studies, meaning that their effects may be manifest via interacting downstream tr...