objective(s): considering the fact that the standardized uptake value (suv) of a normal lung tissue is expressed as x±sd, x+3×sd could be considered as the threshold value to outline the internal tumor volume (itv) of a lung neoplasm. methods: three hollow models were filled with 55.0 kbq/ml fluorine18- fluorodeoxyglucose (18f-fdg) to represent tumors. the models were fixed to a barrel filled w...

To build a patient specific respiratory motion model with a low dose, a novel method was proposed that uses a limited number of 3D lung CT volumes with an external respiratory signal. 4D lung CT volumes were acquired for patients with in vitro labeling on the upper abdominal surface. Meanwhile, 3D coordinates of in vitro labeling were measured as external respiratory signals. A sequential corre...

To quantify the in vivo magnitude and distribution of regional compensatory lung growth following extensive lung resection, we performed high-resolution computed tomography at 15- and 30-cmH(2)O transpulmonary pressures and measured air and tissue (including microvascular blood) volumes within and among lobes in six adult male foxhounds, before and after balanced 65% lung resection ( approximat...

It is remarkable that physiologists have paid so little attention in the past to the mechanics of breathing that no adequate data are now on record concerning the pressure-volume characteristics of the chest and lungs in normal men. The literature contains innumerable investigations of the various fractions of the lung volume and the vital capacity and also a number of observations concerning t...

Lung liquid production and reabsorption rates and lung volumes were measured in 99 fetal sheep (119-148 days of gestation) by indicator-dilution methods with the simultaneous use of blue dye dextran (BDD) and radioiodinated serum albumin (RISA). There were no significant differences between rates of lung liquid production or reabsorption by the two methods (n = 71 pairs; paired t-test; Wilcoxon...

INTRODUCTION Atelectasis is a common finding in acute lung injury, leading to increased shunt and hypoxemia. Current treatment strategies aim to recruit alveoli for gas exchange. Improvement in oxygenation is commonly used to detect recruitment, although the assumption that gas exchange parameters adequately represent the mechanical process of alveolar opening has not been proven so far. The ai...

The mechanisms underlying not well-controlled (NWC) asthma remain poorly understood, but accumulating evidence points to peripheral airway dysfunction as a key contributor. The present study tests whether our recently described respiratory system reactance (Xrs) assessment of peripheral airway dysfunction reveals insight into poor asthma control. The aim of this study was to investigate the con...

BACKGROUND The factors determining respiratory mechanics following heart-lung transplantation (HLT) and bilateral lung transplantation (BLT) are incompletely understood. METHODS The dynamic and static lung volumes of 15 patients after HLT (n = 6) and BLT (n = 9) with no evidence of obliterative bronchiolitis were analysed to assess the factors which determine lung volumes following transplant...

It is remarkable that physiologists have paid so little attention in the past to the mechanics of breathing that no adequate data are now on record concerning the pressure-volume characteristics of the chest and lungs in normal men. The literature contains innumerable investigations of the various fractions of the lung volume and the vital capacity and also a number of observations concerning t...

It is remarkable that physiologists have paid so little attention in the past to the mechanics of breathing that no adequate data are now on record concerning the pressure-volume characteristics of the chest and lungs in normal men. The literature contains innumerable investigations of the various fractions of the lung volume and the vital capacity and also a number of observations concerning t...