T-cell large granular lymphocyte leukemia (T-LGLL) is a T-cell lymphoproliferative disorder that has recently been associated with B-cell dyscrasias on a spectrum ranging from dysgammaglobulinemia to lymphoma. To investigate the relationship between clonal B-cell and LGLL lymphoproliferations, we systematically studied lymphocytes in 57 patients with T-LGLL or NK lymphocytosis using flow cytome...

EBER: Epstein-Barr encoded RNA EBV: Epstein-Barr virus LPD: lymphoproliferative disorder MTX: methotrexate RA: rheumatoid arthritis INTRODUCTION For more than 30 years, methotrexate (MTX) has been a mainstay in the treatment of various inflammatory disorders including rheumatoid arthritis (RA) and psoriasis. Off-label use of MTX has expanded in recent years, as it is found to be effective in tr...

INTRODUCTION Because the normal ovary is assumed to be devoid of lymphoid tissue, it is unusual for it to be an initial manifestation of malignant lymphoma. This case is the first report, to our knowledge, of post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation. CASE PRESENTATION Twenty-nine weeks after a living renal transplantation, a 38-year-old Japa...

Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 v...

Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 v...

Gastroenterology Medicine & Research Gastric Post-Transplant Lymphoproliferative Disorder after Allogenic Stem Cell Transplantation Legarda M1, Garcia-Alberdi E2, Lopez-Almaraz R3, Berastegui M4, Irastorza I1,5, Vitoria JC1,5 and Astigarraga I3,5* 1Pediatric Unit, Department of Pediatrics, Cruces University Hospital, Biocruces Bizkaia Health Institute, Spain 2Department Histopathology, 3Pediatr...

we report a case of membranoproliferative glomerulonephritis (mpgn) with igmκ light chain deposits in a patient with chronic hepatitis c infection and simultaneous onset of monoclonal igmκ gammopathy with concurrent small b-cell lymphoproliferative disease. the patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease ...

Lymphoproliferative disorders are heterogeneous malignancy characterized by the expansion of a lymphoid clone more or less differentiated. At the level of the oral cavity, the lymphoproliferative disorder can occur in various ways, most commonly as lymphoid lesions with extranodal externalization, but sometimes, oral lesions may represent a localization of a disease spread. With regard to the p...