BACKGROUND Posttransplant lymphoproliferative disorders (PTLDs) are rare complications following transplantation. Although organ-specific cases have been reported, primary presentation in the thoracic cavity has not been fully characterized. METHODS Eleven cases of PTLD with a primary thoracic presentation were identified among 3,085 solid-organ transplant patients and 1,662 bone marrow trans...

Posttransplant lymphoproliferative disorders (PTLDs) represent a spectrum ranging from Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV+ or EBV- malignant lymphomas. Central nervous system (CNS) PTLDs have not been characterized fully. We reviewed the clinical, radiologic, and pathologic features of 12 primary CNS PTLDs to define them more precisely. Patients included 1...

Post-transplant lymphoproliferative disorder (PTLD) is a clearly recognized and potentially life threatening complication after solid organ or bone marrow transplantation. It comprises a spectrum of diseases ranging from infectious mononucleosis and lymphoid hyperplasia to highly aggressive lymphoma. The disease has increased clinical importance in view of the constantly rising number of organ ...

Mature T-cell and natural killer (NK)-cell neoplasms (Table 1) represent a heterogeneous spectrum of post-thymic T-celland NK-cell-derived malignancies. They represent 12% of all nonHodgkin lymphomas (NHLs). Significant geographic variation is noted with increased prevalence of select subtypes [i.e. adult T-cell leukemia/lymphoma (ATLL) and extranodal NK/T-cell lymphoma, nasal type] seen in Asi...

C LRRE~T MODELS of neoplasia indicate a stepwise serie5 of events as the usual mechanism b~ which normal cells become neoplastic cells. I However, ca ncer clinically presents as a full~ malignant lesion capable of causing the death of the host. For this reason, it is presently not possible to trace the entire process that led to this conditIon. The occurrence of lymph0proliferati vc disorders i...

ABSTR ACT: Posttransplant lymphoproliferative disorders (PTLDs) are defined by the 2008 World Health Organization classification. Monomorphic PTLD is the most frequent form; it is usually diagnosed several years after transplantation and nowadays is positive for Epstein–Barr virus in only 50% of cases. Although preventive treatments are not effective, in cases of Epstein–Barr virus reactivation...

Guideline update and changes: This guideline is an updated version of the 2008 guideline, revised to take into account the 2008 WHO guidelines as they apply to the lymphoproliferative disorders. There have been no changes to the sections on histiocytic and dendritic cell neoplasms. The pathology of posttransplant lymphoproliferative disorder is dealt with in the BCSH guideline on this topic. Th...